Tbio NMD3 60S ribosomal export protein NMD3

Protein Summary

Description

Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. Ribosomal 40S and 60S subunits associate in the nucleolus and are exported to the cytoplasm. The protein encoded by this gene is involved in the passage of the 60S subunit through the nuclear pore complex and into the cytoplasm. Several transcript variants exist for this gene, but the full-length natures of only two have been described to date. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• Q96D46
• D3DNM7
• Q9Y2Z6
• hNMD3

Gene Name

• NMD3

Ensembl ID

• ENST00000351193
• ENSP00000307525
• ENSG00000169251
• ENST00000460469
• ENSP00000419004

Symbol

• CGI-07

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.84
drug perturbation	0.71
microRNA	0.69
virus perturbation	0.64
disease perturbation	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.6   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 120   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.6   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0