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Tchem
ORAI1
Calcium release-activated calcium channel protein 1

Protein Summary
Description
Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928). CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901). The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000617316
  • ENSP00000482568
  • ENSG00000276045

Symbol
  • CRACM1
  • TMEM142A
  • IMD9
  • TAM2
  • ORAT1
  • CRACM1
  • TMEM142A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.91
molecular function
0.84
transcription factor
0.79
biological term
0.65
tissue sample
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 602.32   (req: < 5)
Gene RIFs: 276   (req: <= 3)
Antibodies: 449   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 602.32   (req: >= 5)
Gene RIFs: 276   (req: > 3)
Antibodies: 449   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (102)
TTC28
Tdark
Novelty:  0.16651519
p_int:  0.999663048
p_ni:  0.000336931
p_wrong:  2.1e-8
Data Source:  BioPlex
HSD17B7
Tchem
Family:  Enzyme
Novelty:  0.04295724
p_int:  0.990462556
p_ni:  0.00940399
p_wrong:  0.000133453
Data Source:  BioPlex
ATP7A
Tbio
Family:  Enzyme
Novelty:  0.00064155
p_int:  0.987440846
p_ni:  0.004480228
p_wrong:  0.008078925
Data Source:  BioPlex
CYP2S1
Tbio
Novelty:  0.02967417
p_int:  0.987317098
p_ni:  0.008629537
p_wrong:  0.004053365
Data Source:  BioPlex
SLC35F6
Tbio
Family:  Transporter
Novelty:  1.05410124
p_int:  0.970875582
p_ni:  0.028962947
p_wrong:  0.000161471
Data Source:  BioPlex
ARFGEF1
Tbio
Novelty:  0.16148196
p_int:  0.968944177
p_ni:  0.031055823
Data Source:  BioPlex
ARFGEF2
Tbio
Novelty:  0.05568966
p_int:  0.968615972
p_ni:  0.031384028
Data Source:  BioPlex
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.943552221
p_ni:  0.056447779
Data Source:  BioPlex
GHITM
Tbio
Novelty:  0.00360652
p_int:  0.939873819
p_ni:  0.060126181
Data Source:  BioPlex
SLC25A6
Tchem
Family:  Transporter
Novelty:  0.0052748
p_int:  0.936370651
p_ni:  0.063629349
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
Cardiac conduction
Reactome
Elevation of cytosolic Ca2+ levels
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Cardiac conduction
Elevation of cytosolic Ca2+ levels
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
83.2
self reported educational attainment
1
1
1
40.7
Agents acting on the renin-angiotensin system use measurement
1
1
1
38.2
Calcium channel blocker use measurement
1
1
1
37.6
grip strength measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
83.2
self reported educational attainment
1
40.7
Agents acting on the renin-angiotensin system use measurement
1
38.2
Calcium channel blocker use measurement
1
37.6
grip strength measurement
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ORAI calcium release-activated calcium modulator 1
700190
Mouse
MGI:1925542
109305
Rat
RGD:1311873
304496
Dog
ORAI calcium release-activated calcium modulator 1
VGNC:44137
486261
Horse
ORAI calcium release-activated calcium modulator 1
VGNC:21048
100059726
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ORAI calcium release-activated calcium modulator 1
Mouse
Rat
Dog
ORAI calcium release-activated calcium modulator 1
Horse
ORAI calcium release-activated calcium modulator 1
Publication Statistics
PubMed Score 602.32
PubMed score by year
PubTator Score 441.68
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title