ORAI1
Calcium release-activated calcium channel protein 1
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor binding site profile | 0.91 | ||
molecular function | 0.84 | ||
transcription factor | 0.79 | ||
biological term | 0.65 | ||
tissue sample | 0.6 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
Reactome | Cardiac conduction | ||||
Reactome | Elevation of cytosolic Ca2+ levels | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
Cardiac conduction | ||||
Elevation of cytosolic Ca2+ levels | ||||
Hemostasis | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean reticulocyte volume | 1 | 1 | 1 | 83.2 | |||||
self reported educational attainment | 1 | 1 | 1 | 40.7 | |||||
Agents acting on the renin-angiotensin system use measurement | 1 | 1 | 1 | 38.2 | |||||
Calcium channel blocker use measurement | 1 | 1 | 1 | 37.6 | |||||
grip strength measurement | 1 | 1 | 1 | 35 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean reticulocyte volume | 1 | 83.2 | |||||
self reported educational attainment | 1 | 40.7 | |||||
Agents acting on the renin-angiotensin system use measurement | 1 | 38.2 | |||||
Calcium channel blocker use measurement | 1 | 37.6 | |||||
grip strength measurement | 1 | 35 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | ORAI calcium release-activated calcium modulator 1 | 700190 | ||||||
Mouse | MGI:1925542 | 109305 | ||||||
Rat | RGD:1311873 | 304496 | ||||||
Dog | ORAI calcium release-activated calcium modulator 1 | VGNC:44137 | 486261 | |||||
Horse | ORAI calcium release-activated calcium modulator 1 | VGNC:21048 | 100059726 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | ORAI calcium release-activated calcium modulator 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ORAI calcium release-activated calcium modulator 1 | |||||
Horse | ORAI calcium release-activated calcium modulator 1 | |||||
PMID | Year | Title |
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