Tchem ORAI1 Calcium release-activated calcium channel protein 1

Protein Classes

DTO Classes

Protein / Ion Channel / Calcium Release-activated Calcium (Crac) Channel (Crac-c) Family / Calcium Release-activated Calcium Channel Protein 1

Protein Summary

Description

Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928). CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901). The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q96D31
• Q3MHV3
• Q6DHX2
• Q96BP7
• Q96K71

Gene Name

• ORAI1

Ensembl ID

• ENST00000617316
• ENSP00000482568
• ENSG00000276045

Symbol

• CRACM1
• TMEM142A
• IMD9
• TAM2
• ORAT1
• CRACM1
• TMEM142A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.91
molecular function	0.84
transcription factor	0.79
biological term	0.65
tissue sample	0.6

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 580.9   (req: < 5)

Gene RIFs: 276   (req: <= 3)

Antibodies: 449   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 580.9   (req: >= 5)

Gene RIFs: 276   (req: > 3)

Antibodies: 449   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (16)

Explore Active Ligands

1 – 10 of 16

CHEMBL262766

ORAI1Tchem IC

IC50 : 5.55

CM4620

ORAI1Tchem IC

IC50 : 6.92000008

GSK-7975A

ORAI1Tchem IC

IC50 : 6.4000001

CHEMBL3984105

ORAI1Tchem IC

IC50 : 7.58

CHEMBL3403753

ORAI1Tchem IC

IC50 : 6.36

CHEMBL3699934

ORAI1Tchem IC

IC50 : 6.42

CHEMBL3699937

ORAI1Tchem IC

IC50 : 6.58

CHEMBL3699933

ORAI1Tchem IC

IC50 : 6.74

CHEMBL3699942

ORAI1Tchem IC

IC50 : 6.79

CHEMBL3699936

ORAI1Tchem IC

IC50 : 6.83

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	ORAI calcium release-activated calcium modulator 1		700190
Mouse	ORAI calcium release-activated calcium modulator 1	MGI:1925542	109305
Rat	ORAI calcium release-activated calcium modulator 1	RGD:1311873	304496
Dog	ORAI calcium release-activated calcium modulator 1	VGNC:44137	486261
Horse	ORAI calcium release-activated calcium modulator 1	VGNC:21048	100059726

Species	Name	OMA	EggNOG	Inparanoid
Macaque	ORAI calcium release-activated calcium modulator 1
Mouse	ORAI calcium release-activated calcium modulator 1
Rat	ORAI calcium release-activated calcium modulator 1
Dog	ORAI calcium release-activated calcium modulator 1
Horse	ORAI calcium release-activated calcium modulator 1

Protein Structure (2 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96D31-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (21)

Reactome (11)

KEGG (8)

PathwayCommons (2)

Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 11

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	92 targets	R-HSA-983695
Reactome	Cardiac conduction	137 targets	R-HSA-5576891
Reactome	Elevation of cytosolic Ca2+ levels	16 targets	R-HSA-139853
Reactome	Hemostasis	666 targets	R-HSA-109582

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	92 targets	R-HSA-983695
Cardiac conduction	137 targets	R-HSA-5576891
Elevation of cytosolic Ca2+ levels	16 targets	R-HSA-139853
Hemostasis	666 targets	R-HSA-109582

Gene Ontology Terms (17)

Functions (3)

Components (7)

Processes (7)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
store-operated calcium channel activity	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
calmodulin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (102)

Explore Interacting Targets

1 – 10 of 102

• See Interactions on String-DB

TTC28

Tdark

Novelty: 0.16651519

p_int: 0.999663048

p_ni: 0.000336931

p_wrong: 2.1e-8

Data Source: BioPlex

HSD17B7

Tchem

Family: Enzyme

Novelty: 0.04295724

p_int: 0.990462556

p_ni: 0.00940399

p_wrong: 0.000133453

Data Source: BioPlex

ATP7A

Tbio

Family: Enzyme

Novelty: 0.00064155

p_int: 0.987440846

p_ni: 0.004480228

p_wrong: 0.008078925

Data Source: BioPlex

CYP2S1

Tbio

Novelty: 0.02967417

p_int: 0.987317098

p_ni: 0.008629537

p_wrong: 0.004053365

Data Source: BioPlex

SLC35F6

Tbio

Family: Transporter

Novelty: 1.05410124

p_int: 0.970875582

p_ni: 0.028962947

p_wrong: 0.000161471

Data Source: BioPlex

ARFGEF1

Tbio

Novelty: 0.16148196

p_int: 0.968944177

p_ni: 0.031055823

Data Source: BioPlex

ARFGEF2

Tbio

Novelty: 0.05568966

p_int: 0.968615972

p_ni: 0.031384028

Data Source: BioPlex

TUBB3

Tclin

Novelty: 0.00195963

p_int: 0.943552221

p_ni: 0.056447779

Data Source: BioPlex

GHITM

Tbio

Novelty: 0.00360652

p_int: 0.939873819

p_ni: 0.060126181

Data Source: BioPlex

SLC25A6

Tbio

Family: Transporter

Novelty: 0.0052748

p_int: 0.936370651

p_ni: 0.063629349

Data Source: BioPlex

Publication Statistics

PubMed Score  580.90

PubMed score by year

Reset Zoom

PubTator Score  441.68

PubTator score by year

Reset Zoom

Patents

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

3D-structure
Adaptive immunity
Alternative initiation
Calcium
Calcium channel
Calcium transport
Calmodulin-binding
Cell membrane
Complete proteome
Disease mutation

MGI Phenotype Find Similar Targets

cellular phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
mortality/aging
nervous system phenotype