ORAI1
Calcium release-activated calcium channel protein 1
Protein Summary
Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928). CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901). The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]
- ENST00000617316
- ENSP00000482568
- ENSG00000276045
- CRACM1
- TMEM142A
- IMD9
- TAM2
- ORAT1
- CRACM1
- TMEM142A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.91 | ||
molecular function | 0.84 | ||
transcription factor | 0.79 | ||
biological term | 0.65 | ||
tissue sample | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 602.32 (req: < 5)
Gene RIFs: 276 (req: <= 3)
Antibodies: 449 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 602.32 (req: >= 5)
Gene RIFs: 276 (req: > 3)
Antibodies: 449 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 16
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (16)
Protein-Protein Interactions (102)
TTC28
Novelty: 0.16651519
p_int: 0.999663048
p_ni: 0.000336931
p_wrong: 2.1e-8
Data Source: BioPlex
HSD17B7
Family: Enzyme
Novelty: 0.04295724
p_int: 0.990462556
p_ni: 0.00940399
p_wrong: 0.000133453
Data Source: BioPlex
ATP7A
Family: Enzyme
Novelty: 0.00064155
p_int: 0.987440846
p_ni: 0.004480228
p_wrong: 0.008078925
Data Source: BioPlex
CYP2S1
Novelty: 0.02967417
p_int: 0.987317098
p_ni: 0.008629537
p_wrong: 0.004053365
Data Source: BioPlex
SLC35F6
Family: Transporter
Novelty: 1.05410124
p_int: 0.970875582
p_ni: 0.028962947
p_wrong: 0.000161471
Data Source: BioPlex
SLC25A6
Family: Transporter
Novelty: 0.0052748
p_int: 0.936370651
p_ni: 0.063629349
Data Source: BioPlex
Nearest Tclin Targets
Pathways (21)
Reactome (11)
KEGG (8)
PathwayCommons (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
Reactome | Cardiac conduction | ||||
Reactome | Elevation of cytosolic Ca2+ levels | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
Cardiac conduction | ||||
Elevation of cytosolic Ca2+ levels | ||||
Hemostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (3)
Components (7)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean reticulocyte volume | 1 | 1 | 1 | 83.2 | |||||
self reported educational attainment | 1 | 1 | 1 | 40.7 | |||||
Agents acting on the renin-angiotensin system use measurement | 1 | 1 | 1 | 38.2 | |||||
Calcium channel blocker use measurement | 1 | 1 | 1 | 37.6 | |||||
grip strength measurement | 1 | 1 | 1 | 35 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean reticulocyte volume | 1 | 83.2 | |||||
self reported educational attainment | 1 | 40.7 | |||||
Agents acting on the renin-angiotensin system use measurement | 1 | 38.2 | |||||
Calcium channel blocker use measurement | 1 | 37.6 | |||||
grip strength measurement | 1 | 35 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | ORAI calcium release-activated calcium modulator 1 | 700190 | ||||||
Mouse | MGI:1925542 | 109305 | ||||||
Rat | RGD:1311873 | 304496 | ||||||
Dog | ORAI calcium release-activated calcium modulator 1 | VGNC:44137 | 486261 | |||||
Horse | ORAI calcium release-activated calcium modulator 1 | VGNC:21048 | 100059726 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | ORAI calcium release-activated calcium modulator 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ORAI calcium release-activated calcium modulator 1 | |||||
Horse | ORAI calcium release-activated calcium modulator 1 | |||||
Publication Statistics
PubMed Score 602.32
PubMed score by year
PubTator Score 441.68
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (293)
GeneRif Annotations (276)
Items per page:
0 of 0
PMID | Year | Title |
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