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Tbio
NTNG2
Netrin-G2

Protein Summary
Description
Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372179
  • ENSP00000361252
  • ENSG00000196358
  • ENST00000393229
  • ENSP00000376921

Symbol
  • KIAA1857
  • LMNT2
  • Lmnt2
  • NTNG1
  • LHLL9381
  • bA479K20.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
transcription factor
0.59
protein domain
0.58
histone modification site profile
0.55
PubMedID
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.89   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.89   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
2
43.9
mathematical ability
1
1
1
6.1
cognitive function measurement
1
1
1
2.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
43.9
mathematical ability
1
6.1
cognitive function measurement
1
2.2
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
netrin G2
VGNC:13936
464813
Macaque
netrin G2
715127
Mouse
MGI:2159341
171171
Rat
RGD:1307089
311836
Cow
netrin G2
VGNC:32308
523720
Species
Name
OMA
EggNOG
Inparanoid
Chimp
netrin G2
Macaque
netrin G2
Mouse
Rat
Cow
netrin G2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96CW9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Gene Ontology Terms (15)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (135)
1 – 10 of 135
LRRC4
Tbio
Novelty:  0.03600857
Score:  0.977
Data Source:  STRINGDB
MDGA1
Tbio
Novelty:  0.04478487
Score:  0.935
Data Source:  STRINGDB
CNTN4
Tbio
Novelty:  0.02483465
Score:  0.927
Data Source:  STRINGDB
NEGR1
Tbio
Novelty:  0.0088917
Score:  0.92
Data Source:  STRINGDB
OPCML
Tbio
Novelty:  0.01569352
Score:  0.918
Data Source:  STRINGDB
CNTN3
Tbio
Novelty:  0.0055725
Score:  0.915
Data Source:  STRINGDB
NTM
Tbio
Novelty:  0.01659865
Score:  0.915
Data Source:  STRINGDB
LSAMP
Tbio
Novelty:  0.01237032
Score:  0.914
Data Source:  STRINGDB
RTN4RL1
Tbio
Novelty:  0.07113722
Score:  0.91
Data Source:  STRINGDB
RTN4RL2
Tbio
Novelty:  0.05919593
Score:  0.907
Data Source:  STRINGDB
Publication Statistics
PubMed Score  36.89

PubMed score by year
PubTator Score  8.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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