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Tbio
OPTN
Optineurin

Protein Summary
Description
Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263036
  • ENSP00000263036
  • ENSG00000123240
  • ENST00000378747
  • ENSP00000368021
  • ENST00000378748
  • ENSP00000368022
  • ENST00000378752
  • ENSP00000368027
  • ENST00000378757
  • ENSP00000368032
  • ENST00000378764
  • ENSP00000368040

Symbol
  • FIP2
  • GLC1E
  • HIP7
  • HYPL
  • NRP
  • NRP
  • FIP2
  • HIP7
  • HYPL
  • ALS12
  • GLC1E
  • TFIIIA-INTP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.98
disease perturbation
0.95
kinase perturbation
0.91
cellular component
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1691.63   (req: < 5)
Gene RIFs: 132   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1691.63   (req: >= 5)
Gene RIFs: 132   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (228)
STX12
Tbio
Novelty:  0.03836262
p_int:  0.999999986
p_ni:  6e-9
p_wrong:  8e-9
Data Source:  BioPlex
AIMP1
Tbio
Family:  Enzyme
Novelty:  0.00743447
p_int:  0.999997342
p_ni:  0.000002658
Score:  0.19
Data Source:  BioPlex,STRINGDB
RAB3IL1
Tbio
Novelty:  0.0167537
p_int:  0.999985852
p_ni:  0.000014144
p_wrong:  4e-9
Score:  0.255
Data Source:  BioPlex,STRINGDB
TNIP1
Tbio
Novelty:  0.0147254
p_int:  0.999881254
p_ni:  0.0000575
p_wrong:  0.000061245
Score:  0.476
Data Source:  BioPlex,STRINGDB
WDR20
Tbio
Novelty:  0.03031804
p_int:  0.999522103
p_ni:  0.000143918
p_wrong:  0.000333979
Score:  0.189
Data Source:  BioPlex,STRINGDB
ZMYM6
Tbio
Novelty:  0.4933879
p_int:  0.990652169
p_ni:  0.009347831
Data Source:  BioPlex
TRIM16
Tbio
Novelty:  0.03987217
p_int:  0.7718292
p_ni:  0.000034128
p_wrong:  0.228136672
Score:  0.403
Data Source:  BioPlex,STRINGDB
TBK1
Tchem
Family:  Kinase
Novelty:  0.00194753
Score:  0.995
Data Source:  STRINGDB
RAB8A
Tbio
Family:  Enzyme
Novelty:  0.00486694
Score:  0.985
Data Source:  Reactome,STRINGDB
MAP1LC3B
Tbio
Novelty:  0.00101276
Score:  0.983
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Cell Cycle (R-HSA-1640170)

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Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
G2/M Transition
Reactome
Membrane Trafficking
Reactome
Mitotic G2-G2/M phases
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
G2/M Transition
Membrane Trafficking
Mitotic G2-G2/M phases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.6
94.4
brain measurement
1
1
0
9.7
64.8
cortical surface area measurement
1
1
0
8.6
59.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
94.4
brain measurement
0
9.7
64.8
cortical surface area measurement
0
8.6
59.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
optineurin
VGNC:4972
736417
Macaque
optineurin
574252
Mouse
MGI:1918898
71648
Rat
RGD:628886
246294
Dog
optineurin
VGNC:44136
478003
Species
Name
OMA
EggNOG
Inparanoid
Chimp
optineurin
Macaque
optineurin
Mouse
Rat
Dog
optineurin
Publication Statistics
PubMed Score 1691.63
PubMed score by year
PubTator Score 435.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title