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Tdark
CCDC124
Coiled-coil domain-containing protein 124

Protein Summary
Description
Required for proper progression of late cytokinetic stages.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000445755
  • ENSP00000408730
  • ENSG00000007080
  • ENST00000597436
  • ENSP00000471455
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
histone modification site profile
0.92
transcription factor
0.9
interacting protein
0.82
tissue sample
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.32   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.32   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
3
87.4
monocyte percentage of leukocytes
2
1
2
81.9
reticulocyte measurement
2
3
3
78.4
monocyte count
1
1
1
72.3
reticulocyte count
1
2
2
68.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
87.4
monocyte percentage of leukocytes
2
81.9
reticulocyte measurement
3
78.4
monocyte count
1
72.3
reticulocyte count
2
68.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 124
VGNC:3638
455849
Mouse
MGI:1916403
234388
Rat
RGD:1310931
290642
Dog
coiled-coil domain containing 124
476671
Horse
coiled-coil domain containing 124
VGNC:16116
100146857
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 124
Mouse
Rat
Dog
coiled-coil domain containing 124
Horse
coiled-coil domain containing 124
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96CT7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (36)
1 – 10 of 36
EIF3J
Tbio
Novelty:  0.04648652
Score:  0.764
Data Source:  STRINGDB
PRKRA
Tbio
Family:  Kinase
Novelty:  0.02115618
Score:  0.742
Data Source:  STRINGDB
ZNF346
Tbio
Novelty:  0.00204191
Score:  0.742
Data Source:  STRINGDB
AURKAIP1
Tchem
Family:  Enzyme
Novelty:  0.19241693
Score:  0.739
Data Source:  STRINGDB
CCDC77
Tdark
Novelty:  2.54727442
Score:  0.718
Data Source:  STRINGDB
UFSP2
Tbio
Family:  Enzyme
Novelty:  0.12630722
Score:  0.682
Data Source:  STRINGDB
PARPBP
Tbio
Novelty:  0.0886089
Score:  0.669
Data Source:  STRINGDB
MRPL40
Tbio
Novelty:  0.09916967
Score:  0.648
Data Source:  STRINGDB
TUBGCP2
Tbio
Novelty:  0.01856674
Score:  0.629
Data Source:  STRINGDB
TGIF2LX
Tbio
Family:  TF
Novelty:  0.10755032
Score:  0.626
Data Source:  STRINGDB
Publication Statistics
PubMed Score  4.32

PubMed score by year
PubTator Score  1.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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