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Tbio
PLEKHB2
Pleckstrin homology domain-containing family B member 2

Protein Summary
Description
Involved in retrograde transport of recycling endosomes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234115
  • ENSP00000234115
  • ENSG00000115762
  • ENST00000409158
  • ENSP00000386410
  • ENST00000409279
  • ENSP00000386666
  • ENST00000409612
  • ENSP00000386662
  • ENST00000438882
  • ENSP00000401193
  • ENST00000628582
  • ENSP00000487321

Symbol
  • EVT2
  • EVT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
disease perturbation
0.79
microRNA
0.79
virus perturbation
0.79
transcription factor binding site profile
0.66


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.76   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.76   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
pleckstrin homology domain containing B2
720588
Mouse
MGI:2385825
226971
Rat
RGD:1310954
301337
Dog
pleckstrin homology domain containing B2
VGNC:44673
483858
Horse
pleckstrin homology domain containing B2
VGNC:21564
100068341
Species
Name
OMA
EggNOG
Inparanoid
Macaque
pleckstrin homology domain containing B2
Mouse
Rat
Dog
pleckstrin homology domain containing B2
Horse
pleckstrin homology domain containing B2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96CS7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Protein-Protein Interactions (20)
1 – 10 of 20
TMEM231
Tbio
Novelty: 0.17100188
p_int: 0.950532224
p_ni: 0.009776117
p_wrong: 0.039691659
Score: 0.188
Data Source: BioPlex,STRINGDB
CST6
Tbio
Novelty: 0.02811473
p_int: 0.899537683
p_ni: 0.098812359
p_wrong: 0.001649957
Score: 0.189
Data Source: BioPlex,STRINGDB
CGRRF1
Tdark
Novelty: 0.49690187
p_int: 0.795240847
p_ni: 0.000846662
p_wrong: 0.203912491
Score: 0.187
Data Source: BioPlex,STRINGDB
CELF4
Tbio
Novelty: 0.02895323
Score: 0.607
Data Source: STRINGDB
ASB1
Tdark
Novelty: 0.0931554
Score: 0.606
Data Source: STRINGDB
PLEKHH3
Tdark
Novelty: 2.43915121
Score: 0.563
Data Source: STRINGDB
AMER3
Tdark
Novelty: 0.42348252
Score: 0.543
Data Source: STRINGDB
FAM168B
Tdark
Novelty: 0.18441993
Score: 0.531
Data Source: STRINGDB
PLEKHG1
Tbio
Novelty: 0.18355652
Score: 0.531
Data Source: STRINGDB
ATP8A1
Tbio
Family: Transporter
Novelty: 0.02003643
Score: 0.51
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.76

PubMed score by year
PubTator Score  5.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer