You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FAF2
FAS-associated factor 2

Protein Summary
Description
Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis (PubMed:23297223). The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261942
  • ENSP00000261942
  • ENSG00000113194

Symbol
  • ETEA
  • KIAA0887
  • UBXD8
  • UBXN3B
  • ETEA
  • UBXD8
  • UBXN3B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
virus perturbation
0.95
histone modification site profile
0.91
kinase perturbation
0.84
transcription factor binding site profile
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.37   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.37   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (294)
SETDB1
Tbio
Family:  TF; Epigenetic
Novelty:  0.00609294
p_int:  0.999995156
p_ni:  0.000004844
Score:  0.382
Data Source:  BioPlex,STRINGDB
CLEC11A
Tbio
Novelty:  0.03060601
p_int:  0.999981438
p_ni:  0.000018562
Data Source:  BioPlex
ARL14EP
Tdark
Novelty:  0.58569411
p_int:  0.999962467
p_ni:  0.000035589
p_wrong:  0.000001944
Score:  0.185
Data Source:  BioPlex,STRINGDB
TMEM159
Tdark
Novelty:  0.22237677
p_int:  0.999889572
p_ni:  0.000110426
p_wrong:  2e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.999841259
p_ni:  0.000158741
Score:  0.287
Data Source:  BioPlex,STRINGDB
MFN1
Tbio
Novelty:  0.00372574
p_int:  0.999764983
p_ni:  0.000235017
Score:  0.2
Data Source:  BioPlex,STRINGDB
FUNDC2
Tbio
Novelty:  0.09695817
p_int:  0.999644783
p_ni:  0.000355217
Data Source:  BioPlex
MCUR1
Tbio
Novelty:  0.06505266
p_int:  0.99964027
p_ni:  0.0000016
p_wrong:  0.00035813
Score:  0.216
Data Source:  BioPlex,STRINGDB
CAV1
Tbio
Novelty:  0.00035244
p_int:  0.99960071
p_ni:  0.000381592
p_wrong:  0.000017698
Data Source:  BioPlex
SARAF
Tbio
Novelty:  0.0383833
p_int:  0.999525733
p_ni:  0.000449958
p_wrong:  0.000024309
Score:  0.487
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fas associated factor family member 2
VGNC:3981
462289
Macaque
Fas associated factor family member 2
702555
Mouse
MGI:1923827
76577
Rat
RGD:1306577
291000
Dog
Fas associated factor family member 2
VGNC:40568
489102
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fas associated factor family member 2
Macaque
Fas associated factor family member 2
Mouse
Rat
Dog
Fas associated factor family member 2
Publication Statistics
PubMed Score 33.37
PubMed score by year
PubTator Score 11.54
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title