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Tdark
TLCD1
Calfacilitin

Protein Summary
Description
Calcium channel facilitator that increases calcium flux by generating a larger window current and slowing inactivation of the L-type CACNA1C/CaV1.2 channel. Regulation of intracellular calcium by Calfacilitin is required for neural plate formation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292090
  • ENSP00000292090
  • ENSG00000160606
  • ENST00000394933
  • ENSP00000378391
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.91
transcription factor
0.76
histone modification site profile
0.64
transcription factor perturbation
0.61
tissue sample
0.6


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.87   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.87   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TLC domain containing 1
VGNC:9712
454533
Mouse
MGI:1915572
68385
Rat
RGD:1359195
287472
Dog
TLC domain containing 1
VGNC:47393
480628
Horse
TLC domain containing 1
VGNC:24126
100059417
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TLC domain containing 1
Mouse
Rat
Dog
TLC domain containing 1
Horse
TLC domain containing 1
Gene Ontology Terms (2)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (16)
1 – 10 of 16
SLC6A15
Tchem
Family: Transporter
Novelty: 0.04011524
p_int: 0.999969972
p_ni: 0.000030027
p_wrong: 1e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
SPPL2B
Tbio
Family: Enzyme
Novelty: 0.0274774
p_int: 0.995614708
p_ni: 0.003178699
p_wrong: 0.001206593
Score: 0.159
Data Source: BioPlex,STRINGDB
SLC39A12
Tbio
Family: Transporter
Novelty: 0.09127395
p_int: 0.99554295
p_ni: 0.003096583
p_wrong: 0.001360467
Data Source: BioPlex
THTPA
Tbio
Family: Enzyme
Novelty: 0.06922501
Score: 0.77
Data Source: STRINGDB
NUDT21
Tbio
Novelty: 0.02174736
Score: 0.764
Data Source: STRINGDB
CPSF7
Tbio
Novelty: 0.13068955
Score: 0.742
Data Source: STRINGDB
NRSN1
Tbio
Novelty: 0.05150409
Score: 0.726
Data Source: STRINGDB
GMNN
Tbio
Novelty: 0.00436572
Score: 0.71
Data Source: STRINGDB
FXYD6
Tbio
Family: IC
Novelty: 0.0503209
Score: 0.658
Data Source: STRINGDB
IWS1
Tbio
Novelty: 0.08732963
Score: 0.654
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.87

PubMed score by year
PubTator Score  1.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer