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Tbio
ACSF2
Acyl-CoA synthetase family member 2, mitochondrial

Protein Summary
Description
Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300441
  • ENSP00000300441
  • ENSG00000167107
  • ENST00000427954
  • ENSP00000401831
  • ENST00000502667
  • ENSP00000421884

Symbol
  • ACSMW
  • AVYV493
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
molecular function
0.81
interacting protein
0.71
tissue sample
0.63
kinase perturbation
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.18   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.18   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
58.3
heel bone mineral density
1
1
1
2.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
58.3
heel bone mineral density
1
2.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase family member 2
VGNC:12024
455121
Macaque
acyl-CoA synthetase family member 2
702474
Mouse
MGI:2388287
264895
Rat
RGD:1562656
619561
Dog
acyl-CoA synthetase family member 2
VGNC:37530
480551
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase family member 2
Macaque
acyl-CoA synthetase family member 2
Mouse
Rat
Dog
acyl-CoA synthetase family member 2
Pathways (5)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Mitochondrial Fatty Acid Beta-Oxidation
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Metabolism
Metabolism of lipids
Mitochondrial Fatty Acid Beta-Oxidation
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (77)
1 – 10 of 77
MRPL12
Tbio
Novelty: 0.10646542
p_int: 0.999984846
p_ni: 0.000015154
p_wrong: 1e-9
Score: 0.17
Data Source: BioPlex,STRINGDB
SLC6A20
Tbio
Family: Transporter
Novelty: 0.01435823
p_int: 0.999843517
p_ni: 0.000156482
p_wrong: 2e-9
Data Source: BioPlex
ACSM5
Tbio
Family: Enzyme
Novelty: 0.11562771
p_int: 0.999520755
p_ni: 0.000479245
Score: 0.32
Data Source: BioPlex,STRINGDB
NIT1
Tbio
Family: Enzyme
Novelty: 0.00498587
p_int: 0.999500602
p_ni: 0.000499398
Score: 0.229
Data Source: BioPlex,STRINGDB
WDR44
Tdark
Novelty: 0.02158824
p_int: 0.998958578
p_ni: 0.001041364
p_wrong: 5.8e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
PPA2
Tbio
Family: Enzyme
Novelty: 0.01790138
p_int: 0.998410526
p_ni: 0.001589474
Score: 0.498
Data Source: BioPlex,STRINGDB
BPNT1
Tbio
Family: Enzyme
Novelty: 0.1114547
p_int: 0.997449201
p_ni: 0.002550718
p_wrong: 8.1e-8
Score: 0.172
Data Source: BioPlex,STRINGDB
HSPD1
Tbio
Novelty: 0.00018924
p_int: 0.997231224
p_ni: 0.002768776
Score: 0.206
Data Source: BioPlex,STRINGDB
GNB2
Tbio
Novelty: 0.08682553
p_int: 0.953536562
p_ni: 0.046460636
p_wrong: 0.000002802
Data Source: BioPlex
LIPE
Tchem
Family: Enzyme
Novelty: 0.00169872
Score: 0.766
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.18

PubMed score by year
PubTator Score  2.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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