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Tbio
NXNL1
Nucleoredoxin-like protein 1

Protein Summary
Description
May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods. Retinitis pigmentosa (RP) is a disease that leads to blindness by degeneration of cone photoreceptors. Rods produce factors required for cone viability. The protein encoded by this gene is one of those factors and is similar to a truncated form of thioredoxin. This gene has been proposed to have therapeutic value against RP. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301944
  • ENSP00000305631
  • ENSG00000171773

Symbol
  • TXNL6
  • RDCVF
  • TXNL6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.53
tissue
0.53
gene perturbation
0.51
tissue sample
0.43
phenotype
0.4


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.79   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.79   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
86.1
monocyte count
1
1
1
58.4
reticulocyte measurement
2
1
2
52.4
reticulocyte count
2
1
2
52
monocyte percentage of leukocytes
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
86.1
monocyte count
1
58.4
reticulocyte measurement
2
52.4
reticulocyte count
2
52
monocyte percentage of leukocytes
1
31.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1924446
234404
Rat
RGD:1308296
306342
Dog
nucleoredoxin like 1
VGNC:44074
484836
Cow
nucleoredoxin like 1
VGNC:32377
107132595
Opossum
nucleoredoxin like 1
100014262
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
nucleoredoxin like 1
Cow
nucleoredoxin like 1
Opossum
nucleoredoxin like 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96CM4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (43)
1 – 10 of 43
VSX1
Tbio
Family:  TF
Novelty:  0.01213324
Score:  0.805
Data Source:  STRINGDB
VSX2
Tbio
Family:  TF
Novelty:  0.0046733
Score:  0.746
Data Source:  STRINGDB
C8orf37
Tbio
Novelty:  0.06339955
Score:  0.714
Data Source:  STRINGDB
PAX4
Tbio
Family:  TF
Novelty:  0.00697085
Score:  0.711
Data Source:  STRINGDB
ATXN10
Tbio
Novelty:  0.01008505
Score:  0.672
Data Source:  STRINGDB
TNNI1
Tbio
Novelty:  0.01639536
Score:  0.666
Data Source:  STRINGDB
SP3
Tbio
Family:  TF
Novelty:  0.00119924
Score:  0.647
Data Source:  STRINGDB
PDE6B
Tclin
Family:  Enzyme
Novelty:  0.001105
Score:  0.647
Data Source:  STRINGDB
SLC18A2
Tclin
Family:  Transporter
Novelty:  0.00072341
Score:  0.639
Data Source:  STRINGDB
TNNI3
Tbio
Novelty:  0.00020053
Score:  0.638
Data Source:  STRINGDB
Publication Statistics
PubMed Score  32.79

PubMed score by year
PubTator Score  17.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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