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Tbio
EAF2
ELL-associated factor 2

Protein Summary
Description
Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273668
  • ENSP00000273668
  • ENSG00000145088

Symbol
  • TRAITS
  • U19
  • BM040
  • TRAITS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
virus perturbation
0.85
biological process
0.67
transcription factor binding site profile
0.64
molecular function
0.63


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.4   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.4   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ELL associated factor 2
VGNC:1800
745927
Macaque
ELL associated factor 2
714223
Mouse
MGI:2146616
106389
Rat
RGD:628879
266787
Dog
ELL associated factor 2
VGNC:40172
608554
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ELL associated factor 2
Macaque
ELL associated factor 2
Mouse
Rat
Dog
ELL associated factor 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96CJ1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Formation of RNA Pol II elongation complex (R-HSA-112382)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of RNA Pol II elongation complex
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Pre-transcription Events
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Elongation
Name
Explore in Pharos
Explore in Source
Formation of RNA Pol II elongation complex
Gene expression (Transcription)
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription
RNA Polymerase II Transcription Elongation
Protein-Protein Interactions (81)
1 – 10 of 81
EAF1
Tbio
Novelty: 0.81120425
p_int: 0.999999636
p_ni: 9.9e-8
p_wrong: 2.65e-7
Score: 0.972
Data Source: BioPlex,STRINGDB
AFF4
Tbio
Family: TF
Novelty: 0.02113896
p_int: 0.999996827
p_ni: 0.000003074
p_wrong: 9.9e-8
Score: 0.987
Data Source: BioPlex,STRINGDB
PIP4K2A
Tbio
Family: Kinase
Novelty: 0.01130885
p_int: 0.999968289
p_ni: 0.000014322
p_wrong: 0.000017388
Score: 0.622
Data Source: BioPlex,STRINGDB
ELL3
Tbio
Family: Enzyme
Novelty: 0.18245631
p_int: 0.999795475
p_ni: 2.9e-8
p_wrong: 0.000204496
Score: 0.874
Data Source: BioPlex,STRINGDB
ELL
Tbio
Family: Enzyme
Novelty: 0.00424352
Score: 0.988
Data Source: STRINGDB
TCEA1
Tbio
Novelty: 0.00547888
Score: 0.949
Data Source: STRINGDB
MLLT1
Tbio
Novelty: 0.00328241
Score: 0.916
Data Source: STRINGDB
MLLT3
Tbio
Novelty: 0.00361056
Score: 0.911
Data Source: STRINGDB
POLR2A
Tbio
Family: Enzyme
Novelty: 0.00188323
Score: 0.91
Data Source: STRINGDB
CDK9
Tchem
Family: Kinase
Novelty: 0.00210218
Score: 0.908
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.40

PubMed score by year
PubTator Score  17.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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