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Tbio
CTHRC1
Collagen triple helix repeat-containing protein 1

Protein Summary
Description
May act as a negative regulator of collagen matrix deposition. This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330295
  • ENSP00000330523
  • ENSG00000164932
  • ENST00000520337
  • ENSP00000430550
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
PubMedID
0.93
histone modification site profile
0.67
small molecule perturbation
0.66
tissue sample
0.6


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.58   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.58   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen triple helix repeat containing 1
VGNC:11962
472834
Macaque
collagen triple helix repeat containing 1
694882
Mouse
MGI:1915838
68588
Rat
RGD:628801
282836
Dog
collagen triple helix repeat containing 1
VGNC:49728
100684449
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen triple helix repeat containing 1
Macaque
collagen triple helix repeat containing 1
Mouse
Rat
Dog
collagen triple helix repeat containing 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96CG8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (51)
1 – 10 of 51
FZD6
Tbio
Family: GPCR
Novelty: 0.01425136
Score: 0.958
Data Source: STRINGDB
WNT3A
Tchem
Novelty: 0.00119275
Score: 0.938
Data Source: STRINGDB
ROR2
Tbio
Family: Kinase
Novelty: 0.01698587
Score: 0.919
Data Source: STRINGDB
DVL1
Tchem
Novelty: 0.00356876
Score: 0.918
Data Source: STRINGDB
DVL2
Tbio
Novelty: 0.00833084
Score: 0.909
Data Source: STRINGDB
FZD5
Tbio
Family: GPCR
Novelty: 0.01673829
Score: 0.908
Data Source: STRINGDB
DVL3
Tbio
Novelty: 0.01606014
Score: 0.903
Data Source: STRINGDB
FZD3
Tbio
Family: GPCR
Novelty: 0.00964507
Score: 0.743
Data Source: STRINGDB
FZD9
Tbio
Family: GPCR
Novelty: 0.01414546
Score: 0.71
Data Source: STRINGDB
NTN4
Tbio
Novelty: 0.03056042
Score: 0.649
Data Source: STRINGDB
Publication Statistics
PubMed Score  116.58

PubMed score by year
PubTator Score  54.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer