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Tbio
TIFA
TRAF-interacting protein with FHA domain-containing protein A

Protein Summary
Description
Adapter molecule that plays a key role in the activation of proinflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs) (PubMed:12566447, PubMed:15492226, PubMed:26068852, PubMed:28877472, PubMed:28222186, PubMed:30111836). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism (PubMed:15492226, PubMed:26068852). TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of proinflammatory NF-kappa-B signaling (PubMed:30111836). This gene encodes an adapter protein involved in adaptive and innate immunity. This protein incl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361717
  • ENSP00000354911
  • ENSG00000145365
  • ENST00000500655
  • ENSP00000424231

Symbol
  • T2BP
  • T2BP
  • T6BP
  • TIFAA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.68
virus perturbation
0.64
gene perturbation
0.63
transcription factor perturbation
0.61
transcription factor binding site profile
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.87   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.87   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
78
lymphocyte percentage of leukocytes
1
1
1
73.7
neutrophil percentage of leukocytes
1
1
1
67.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
78
lymphocyte percentage of leukocytes
1
73.7
neutrophil percentage of leukocytes
1
67.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
TRAF interacting protein with forkhead associated domain
700865
Mouse
MGI:2182965
211550
Rat
RGD:1359151
310877
Dog
TRAF interacting protein with forkhead associated domain
VGNC:54373
487905
Horse
TRAF interacting protein with forkhead associated domain
VGNC:24102
100064257
Species
Name
OMA
EggNOG
Inparanoid
Macaque
TRAF interacting protein with forkhead associated domain
Mouse
Rat
Dog
TRAF interacting protein with forkhead associated domain
Horse
TRAF interacting protein with forkhead associated domain
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96CG3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (23)
1 – 10 of 23
GPR156
Tdark
Family:  GPCR
Novelty:  0.39183023
p_int:  0.979770303
p_ni:  2.33e-7
p_wrong:  0.020229464
Score:  0.187
Data Source:  BioPlex,STRINGDB
TRAF2
Tbio
Novelty:  0.00983658
Score:  0.767
Data Source:  STRINGDB
RIPPLY3
Tdark
Novelty:  0.13457311
Score:  0.732
Data Source:  STRINGDB
TRAF6
Tbio
Novelty:  0.00109366
Score:  0.726
Data Source:  Reactome,STRINGDB
UTS2
Tbio
Novelty:  0.00279068
Score:  0.683
Data Source:  STRINGDB
TRAIP
Tbio
Family:  Enzyme
Novelty:  0.04163226
Score:  0.626
Data Source:  STRINGDB
IRAK1
Tchem
Family:  Kinase
Novelty:  0.00170873
Score:  0.551
Data Source:  STRINGDB
TAX1BP1
Tbio
Novelty:  0.02498501
Score:  0.546
Data Source:  STRINGDB
TIFAB
Tbio
Novelty:  0.20747207
Score:  0.524
Data Source:  STRINGDB
TANK
Tbio
Novelty:  0.01003866
Score:  0.468
Data Source:  STRINGDB
Publication Statistics
PubMed Score  11.87

PubMed score by year
PubTator Score  10.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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