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Tbio
CHMP4C
Charged multivesicular body protein 4c

Protein Classes
Protein Summary
Description
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297265
  • ENSP00000297265
  • ENSG00000164695

Symbol
  • SHAX3
  • Shax3
  • SNF7-3
  • VPS32C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.77
gene perturbation
0.76
biological process
0.64
cellular component
0.62
transcription factor perturbation
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.48   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.48   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
2
2
0
1.1
86.8
1
1
0
1.2
37.6
age-related hearing impairment
1
1
0
5.6
21.5
mean platelet volume
1
1
1
12.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
86.8
0
1.2
37.6
age-related hearing impairment
0
5.6
21.5
mean platelet volume
1
12.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
charged multivesicular body protein 4C
VGNC:914
472807
Macaque
charged multivesicular body protein 4C
702310
Mouse
MGI:1913621
66371
Rat
RGD:1564543
361916
Dog
charged multivesicular body protein 4C
VGNC:39224
477926
Species
Name
OMA
EggNOG
Inparanoid
Chimp
charged multivesicular body protein 4C
Macaque
charged multivesicular body protein 4C
Mouse
Rat
Dog
charged multivesicular body protein 4C
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96CF2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Budding and maturation of HIV virion
Reactome
Cellular responses to external stimuli
Reactome
Disease
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Name
Explore in Pharos
Explore in Source
Autophagy
Budding and maturation of HIV virion
Cellular responses to external stimuli
Disease
Endosomal Sorting Complex Required For Transport (ESCRT)
Gene Ontology Terms (24)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (81)
1 – 10 of 81
CHMP2A
Tbio
Novelty:  0.00169253
Score:  0.994
Data Source:  STRINGDB
CHMP5
Tbio
Novelty:  0.03378716
Score:  0.992
Data Source:  STRINGDB
VPS4B
Tchem
Novelty:  0.00788708
Score:  0.992
Data Source:  STRINGDB
VPS4A
Tbio
Novelty:  0.01508121
Score:  0.991
Data Source:  STRINGDB
PDCD6IP
Tbio
Novelty:  0.01836118
Score:  0.99
Data Source:  STRINGDB
VPS25
Tbio
Novelty:  0.03002488
Score:  0.977
Data Source:  STRINGDB
TSG101
Tbio
Novelty:  0.00211746
Score:  0.973
Data Source:  STRINGDB
SNF8
Tbio
Novelty:  0.04841708
Score:  0.971
Data Source:  STRINGDB
CHMP2B
Tbio
Novelty:  0.01116381
Score:  0.97
Data Source:  STRINGDB
VPS37C
Tbio
Novelty:  0.24520685
Score:  0.967
Data Source:  STRINGDB
Publication Statistics
PubMed Score  17.48

PubMed score by year
PubTator Score  10.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer