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Tchem
BIRC7
Baculoviral IAP repeat-containing protein 7

Protein Summary
Description
Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isof ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217169
  • ENSP00000217169
  • ENSG00000101197
  • ENST00000342412
  • ENSP00000345213

Symbol
  • KIAP
  • LIVIN
  • MLIAP
  • RNF50
  • KIAP
  • LIVIN
  • MLIAP
  • RNF50
  • ML-IAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.88
molecular function
0.81
biological term
0.74
cell type or tissue
0.68
protein domain
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.9   (req: < 5)
Gene RIFs: 106   (req: <= 3)
Antibodies: 609   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.9   (req: >= 5)
Gene RIFs: 106   (req: > 3)
Antibodies: 609   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL2063869
chemical structure image
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
baculoviral IAP repeat containing 7
VGNC:13833
746160
Macaque
baculoviral IAP repeat containing 7
697671
Mouse
MGI:2676458
329581
Rat
RGD:1562883
296468
Dog
baculoviral IAP repeat containing 7
VGNC:38463
485969
Species
Name
OMA
EggNOG
Inparanoid
Chimp
baculoviral IAP repeat containing 7
Macaque
baculoviral IAP repeat containing 7
Mouse
Rat
Dog
baculoviral IAP repeat containing 7
Protein Data Bank (13)
1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (37)
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Small cell lung cancer
KEGG
Ubiquitin mediated proteolysis
KEGG
Apoptosis - multiple species
KEGG
Toxoplasmosis
KEGG
Pathways in cancer
Name
Explore in Pharos
Explore in Source
Small cell lung cancer
Ubiquitin mediated proteolysis
Apoptosis - multiple species
Toxoplasmosis
Pathways in cancer
Gene Ontology Terms (17)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (69)
1 – 10 of 69
NFKBIB
Tbio
Novelty: 0.00517222
p_int: 0.999999609
p_ni: 3.66e-7
p_wrong: 2.5e-8
Score: 0.254
Data Source: BioPlex,STRINGDB
OSTM1
Tbio
Novelty: 0.03033192
p_int: 0.999989835
p_ni: 0.000010134
p_wrong: 3.1e-8
Score: 0.204
Data Source: BioPlex,STRINGDB
ZC3H7A
Tbio
Novelty: 0.85618782
p_int: 0.999906491
p_ni: 0.000056862
p_wrong: 0.000036646
Score: 0.54
Data Source: BioPlex,STRINGDB
PCNT
Tbio
Novelty: 0.00369505
p_int: 0.999796075
p_ni: 0.000203925
Score: 0.195
Data Source: BioPlex,STRINGDB
DIABLO
Tbio
Novelty: 0.0007851
p_int: 0.999560991
p_ni: 0.000439009
Score: 0.956
Data Source: BioPlex,STRINGDB
XIAP
Tchem
Family: Enzyme
Novelty: 0.00062268
p_int: 0.997145218
p_ni: 0.002854679
p_wrong: 1.02e-7
Score: 0.779
Data Source: BioPlex,STRINGDB
DHRS4
Tbio
Family: Enzyme
Novelty: 0.02992279
p_int: 0.99349615
p_ni: 0.00650216
p_wrong: 0.00000169
Data Source: BioPlex
CLCN7
Tchem
Family: IC
Novelty: 0.00764796
p_int: 0.986107155
p_ni: 0.013848843
p_wrong: 0.000044001
Score: 0.187
Data Source: BioPlex,STRINGDB
HTRA2
Tbio
Family: Enzyme
Novelty: 0.00343249
p_int: 0.949306096
p_ni: 0.050693904
Score: 0.866
Data Source: BioPlex,STRINGDB
BIRC2
Tchem
Novelty: 0.00199701
p_int: 0.945833652
p_ni: 0.054166348
Score: 0.667
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  261.90

PubMed score by year
PubTator Score  200.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer