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Tbio
ENTR1
Endosome-associated-trafficking regulator 1

Protein Summary
Description
Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis (PubMed:23108400, PubMed:25278552, PubMed:27767179). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400). Plays a role in the formation of cilia (PubMed:27767179). Involved in cargo protein localization, such as PKD2, at primary cilia (PubMed:27767179). Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298537
  • ENSP00000298537
  • ENSG00000165689
  • ENST00000357365
  • ENSP00000349929
  • ENST00000371725
  • ENSP00000360790

Symbol
  • SDCCAG3
  • NY-CO-3
  • SDCCAG3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
histone modification site profile
0.9
kinase perturbation
0.88
virus perturbation
0.85
tissue sample
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.71   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.71   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
ZFYVE27
Tbio
Novelty:  0.0563358
p_int:  0.999999859
p_ni:  1.3e-7
p_wrong:  1.1e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
PIP
Tbio
Novelty:  0.00208509
p_int:  0.999999469
p_ni:  5.31e-7
Data Source:  BioPlex
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
p_int:  0.999990997
p_ni:  0.000008988
p_wrong:  1.5e-8
Score:  0.229
Data Source:  BioPlex,STRINGDB
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.99983153
p_ni:  3.11e-7
p_wrong:  0.000168159
Score:  0.197
Data Source:  BioPlex,STRINGDB
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.99922302
p_ni:  0.000056499
p_wrong:  0.000720481
Data Source:  BioPlex
ANKRD50
Tdark
Novelty:  0.7929169
Score:  0.777
Data Source:  STRINGDB
AP1M1
Tbio
Novelty:  0.029282
Score:  0.686
Data Source:  STRINGDB
VPS26B
Tdark
Novelty:  0.25702869
Score:  0.68
Data Source:  STRINGDB
DNAJC13
Tbio
Novelty:  0.03251995
Score:  0.665
Data Source:  STRINGDB
PTPN13
Tchem
Family:  Enzyme
Novelty:  0.00434963
Score:  0.649
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
14
10
4
1.1
98.8
3
4
1
1.2
96.3
HbA1c measurement
3
3
3
94.5
2
2
0
1.2
93.4
4
4
1
1.1
92.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
98.8
1
1.2
96.3
HbA1c measurement
3
94.5
0
1.2
93.4
1
1.1
92.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serologically defined colon cancer antigen 3
464861
Mouse
MGI:1915362
68112
Rat
RGD:1305930
306322
Dog
endosome associated trafficking regulator 1
VGNC:54700
100688006
Horse
endosome associated trafficking regulator 1
VGNC:54697
100068695
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serologically defined colon cancer antigen 3
Mouse
Rat
Dog
endosome associated trafficking regulator 1
Horse
endosome associated trafficking regulator 1
Publication Statistics
PubMed Score 3.71
PubMed score by year
PubTator Score 3.38
PubTator score by year
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Related Publications
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PMID
Year
Title