Tbio ROPN1L Ropporin-1-like protein

Protein Summary

Description

Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation. This gene encodes a member of the ropporin family. The encoded protein is present in sperm and interacts with A-kinase anchoring protein, AKAP3, through the amphipathic helix region of AKAP3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• Q96C74
• D3DTC9
• Q9BZX0
• ROPN1-like protein

Gene Name

• ROPN1L

Ensembl ID

• ENST00000274134
• ENSP00000274134
• ENSG00000145491
• ENST00000503804
• ENSP00000421405

Symbol

• ASP
• RSPH11
• ASP
• RSPH11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
transcription factor perturbation	0.68
cell type or tissue	0.67
tissue sample	0.63
transcription factor binding site profile	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.89   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 167   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.89   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0