SYTL4
Synaptotagmin-like protein 4
Protein Summary
Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]
- ENST00000263033
- ENSP00000263033
- ENSG00000102362
- ENST00000276141
- ENSP00000276141
- ENST00000372981
- ENSP00000362072
- ENST00000372989
- ENSP00000362080
- SLP4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
molecular function | 0.79 | ||
cellular component | 0.78 | ||
transcription factor perturbation | 0.74 | ||
cell type or tissue | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 29.53 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 142 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 29.53 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 142 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0