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Tbio
SYTL4
Synaptotagmin-like protein 4

Protein Summary
Description
Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263033
  • ENSP00000263033
  • ENSG00000102362
  • ENST00000276141
  • ENSP00000276141
  • ENST00000372981
  • ENSP00000362072
  • ENST00000372989
  • ENSP00000362080

Symbol
  • SLP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
molecular function
0.79
cellular component
0.78
transcription factor perturbation
0.74
cell type or tissue
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.73   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.73   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
86.4
mean platelet volume
1
1
1
31
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
86.4
mean platelet volume
1
31
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Gene Ontology Terms (19)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (54)
1 – 10 of 54
RAB27B
Tbio
Family: Enzyme
Novelty: 0.01530218
p_int: 1
Score: 0.807
Data Source: BioPlex,STRINGDB
RAB27A
Tchem
Family: Enzyme
Novelty: 0.00369416
p_int: 0.999999998
p_ni: 2e-9
Score: 0.918
Data Source: BioPlex,STRINGDB
RAB3A
Tbio
Family: Enzyme
Novelty: 0.0043532
p_int: 0.999999571
p_ni: 4.19e-7
p_wrong: 1.1e-8
Score: 0.764
Data Source: BioPlex,STRINGDB
RAB8B
Tbio
Family: Enzyme
Novelty: 0.06230082
p_int: 0.999999203
p_ni: 7.97e-7
Score: 0.224
Data Source: BioPlex,STRINGDB
ONECUT2
Tbio
Family: TF
Novelty: 0.00438685
Score: 0.959
Data Source: STRINGDB
STX1A
Tbio
Novelty: 0.00087207
Score: 0.805
Data Source: STRINGDB
RAB8A
Tbio
Family: Enzyme
Novelty: 0.00486694
Score: 0.773
Data Source: STRINGDB
STXBP1
Tbio
Novelty: 0.00339098
Score: 0.746
Data Source: STRINGDB
STX3
Tbio
Novelty: 0.01055819
Score: 0.732
Data Source: STRINGDB
BRS3
Tchem
Family: GPCR
Novelty: 0.00520417
Score: 0.728
Data Source: STRINGDB
Publication Statistics
PubMed Score  26.73

PubMed score by year
PubTator Score  9.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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