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Tbio
DHX58
Probable ATP-dependent RNA helicase DHX58

Protein Summary
Description
Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immun ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251642
  • ENSP00000251642
  • ENSG00000108771

Symbol
  • D11LGP2E
  • LGP2
  • LGP2
  • RLR-3
  • D11LGP2
  • D11lgp2e
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
molecular function
0.99
protein domain
0.73
biological process
0.64
cell type or tissue
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.5   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 342   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.5   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (136)
DDX58
Tbio
Family:  Enzyme
Novelty:  0.00080099
Score:  0.964
Data Source:  STRINGDB
IFIH1
Tbio
Family:  Enzyme
Novelty:  0.00111499
Score:  0.929
Data Source:  STRINGDB
ISG15
Tbio
Novelty:  0.00203781
Score:  0.918
Data Source:  STRINGDB
RSAD2
Tbio
Novelty:  0.0056473
Score:  0.913
Data Source:  STRINGDB
IRF7
Tbio
Family:  TF
Novelty:  0.0021839
Score:  0.908
Data Source:  STRINGDB
MX1
Tbio
Novelty:  0.00072554
Score:  0.866
Data Source:  STRINGDB
MAVS
Tbio
Novelty:  0.00241215
Score:  0.865
Data Source:  STRINGDB
DICER1
Tbio
Family:  Enzyme
Novelty:  0.000306
Score:  0.845
Data Source:  STRINGDB
USP18
Tbio
Family:  Enzyme
Novelty:  0.01087689
Score:  0.844
Data Source:  STRINGDB
OASL
Tbio
Family:  Enzyme
Novelty:  0.01502223
Score:  0.835
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
3
65.7
mean reticulocyte volume
1
1
1
65.6
Thyroid preparation use measurement
1
1
1
61.4
autoimmune thyroid disease
1
1
0
1.1
55.2
serum non-albumin protein measurement
1
1
1
45.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
65.7
mean reticulocyte volume
1
65.6
Thyroid preparation use measurement
1
61.4
autoimmune thyroid disease
0
1.1
55.2
serum non-albumin protein measurement
1
45.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DExH-box helicase 58
VGNC:9257
742679
Macaque
DExH-box helicase 58
709116
Mouse
MGI:1931560
80861
Rat
RGD:1310093
303538
Dog
DExH-box helicase 58
VGNC:39951
607803
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DExH-box helicase 58
Macaque
DExH-box helicase 58
Mouse
Rat
Dog
DExH-box helicase 58
Publication Statistics
PubMed Score 74.50
PubMed score by year
PubTator Score 69.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title