Tbio MIEF2 Mitochondrial dynamics protein MID49

Protein Summary

Description

Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity. This gene encodes an outer mitochondrial membrane protein that functions in the regulation of mitochondrial morphology. It can directly recruit the fission mediator dynamin-related protein 1 (Drp1) to the mitochondrial surface. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• Q96C03
• J3KPT3
• Q6ZRD4
• Q96N07

Gene Name

• MIEF2

Ensembl ID

• ENST00000323019
• ENSP00000323591
• ENSG00000177427
• ENST00000395704
• ENSP00000379056
• ENST00000395706
• ENSP00000379057
• ENST00000640122
• ENSP00000491181
• ENSG00000284495
• ENST00000640339
• ENSP00000492195
• ENST00000640637
• ENSP00000490984

Symbol

• MID49
• SMCR7
• MID49
• SMCR7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.71
cellular component	0.69
transcription factor binding site profile	0.6
tissue	0.58
cell line	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.85   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 46   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.85   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0