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Tbio
TBC1D20
TBC1 domain family member 20

Protein Summary
Description
GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude. This gene encodes a protein that belongs to a family of GTPase activator proteins of Rab-like small GTPases. The encoded protein and its cognate GTPase, Rab1, bind the nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) to mediate viral replication. Depletion of this protein inhibits replication of the virus and HCV infection. Mutations in this gene are associated with Warburg micro syndrome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354200
  • ENSP00000346139
  • ENSG00000125875
  • ENST00000461304
  • ENSP00000432280

Symbol
  • C20orf140
  • WARBM4
  • C20orf140
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
biological process
0.81
cellular component
0.81
virus perturbation
0.72
histone modification site profile
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.21   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.21   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
HLCS
Tchem
Family:  Enzyme
Novelty:  0.01597449
p_int:  0.999932265
p_ni:  2.91e-7
p_wrong:  0.000067444
Score:  0.54
Data Source:  BioPlex,STRINGDB
TPST2
Tbio
Family:  Enzyme
Novelty:  0.02551048
p_int:  0.999717067
p_ni:  0.000007341
p_wrong:  0.000275592
Data Source:  BioPlex
CD70
Tbio
Novelty:  0.00420393
p_int:  0.999427692
p_ni:  0.000001947
p_wrong:  0.000570361
Score:  0.177
Data Source:  BioPlex,STRINGDB
RAB1B
Tbio
Family:  Enzyme
Novelty:  0.02156819
Score:  0.995
Data Source:  Reactome,STRINGDB
RAB1A
Tbio
Family:  Enzyme
Novelty:  0.00307527
Score:  0.978
Data Source:  STRINGDB
USP6
Tbio
Family:  Enzyme
Novelty:  0.00637069
Score:  0.801
Data Source:  STRINGDB
CDC16
Tbio
Novelty:  0.00916715
Score:  0.778
Data Source:  STRINGDB
RAB2A
Tchem
Family:  Enzyme
Novelty:  0.00629151
Score:  0.753
Data Source:  STRINGDB
RABGAP1
Tbio
Family:  Enzyme
Novelty:  0.14270101
Score:  0.75
Data Source:  STRINGDB
RAB3GAP2
Tbio
Family:  Enzyme
Novelty:  0.10321829
Score:  0.728
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Membrane Trafficking
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
TBC1 domain family member 20
716852
Mouse
MGI:1914481
67231
Rat
RGD:1303293
362237
Dog
TBC1 domain family member 20
VGNC:47139
485817
Horse
TBC1 domain family member 20
VGNC:23902
102151098
Species
Name
OMA
EggNOG
Inparanoid
Macaque
TBC1 domain family member 20
Mouse
Rat
Dog
TBC1 domain family member 20
Horse
TBC1 domain family member 20
Publication Statistics
PubMed Score 12.21
PubMed score by year
PubTator Score 5.46
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title