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Tbio
PLD4
Phospholipase D4

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392593
  • ENSP00000376372
  • ENSG00000166428

Symbol
  • C14orf175
  • C14orf175
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.96
cellular component
0.77
tissue sample
0.69
tissue
0.55
cell line
0.47


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.66   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.66   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
25.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
25.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
phospholipase D family member 4
707527
Mouse
MGI:2144765
104759
Rat
RGD:1598308
362792
Dog
phospholipase D family member 4
VGNC:44663
612697
Horse
phospholipase D family member 4
VGNC:21551
100146639
Species
Name
OMA
EggNOG
Inparanoid
Macaque
phospholipase D family member 4
Mouse
Rat
Dog
phospholipase D family member 4
Horse
phospholipase D family member 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96BZ4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Glycerophospholipid biosynthesis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Inositol phosphate metabolism
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Glycerophospholipid biosynthesis
Immune System
Innate Immune System
Inositol phosphate metabolism
Protein-Protein Interactions (97)
1 – 10 of 97
PEMT
Tbio
Family: Enzyme
Novelty: 0.00786252
Score: 0.916
Data Source: STRINGDB
PISD
Tbio
Family: Enzyme
Novelty: 0.00966227
Score: 0.906
Data Source: STRINGDB
SELENOI
Tbio
Family: Enzyme
Novelty: 0.00809865
Score: 0.902
Data Source: STRINGDB
PLPP5
Tbio
Family: Enzyme
Novelty: 0.14757412
Score: 0.902
Data Source: STRINGDB
LCAT
Tbio
Family: Enzyme
Novelty: 0.00307544
Score: 0.902
Data Source: STRINGDB
PLPP4
Tbio
Family: Enzyme
Novelty: 0.22418589
Score: 0.902
Data Source: STRINGDB
PTDSS2
Tbio
Family: Enzyme
Novelty: 0.08551192
Score: 0.901
Data Source: STRINGDB
LPCAT4
Tdark
Family: Enzyme
Novelty: 0.246654
Score: 0.901
Data Source: STRINGDB
CEPT1
Tbio
Family: Enzyme
Novelty: 0.01816476
Score: 0.901
Data Source: STRINGDB
CHPT1
Tbio
Family: Enzyme
Novelty: 0.02875977
Score: 0.901
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.66

PubMed score by year
PubTator Score  2.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer