Tbio SARAF Store-operated calcium entry-associated regulatory factor

Protein Summary

Description

Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.

Uniprot Accession IDs

• Q96BY9
• B3KQQ4
• B7Z9J1
• D3DSU7
• H9MHJ8
• H9MHJ9
• Q53HE8
• Q9UNZ3
• Q9Y683
• SARAF

Gene Name

• SARAF

Ensembl ID

• ENST00000256255
• ENSP00000256255
• ENSG00000133872
• ENST00000545648
• ENSP00000441351

Symbol

• TMEM66
• XTP3
• XTP3
• FOAP-7
• TMEM66
• HSPC035

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.94
kinase perturbation	0.84
transcription factor perturbation	0.74
tissue	0.68
cell type or tissue	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.22   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.22   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0