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Tbio
SARAF
Store-operated calcium entry-associated regulatory factor

Protein Summary
Description
Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256255
  • ENSP00000256255
  • ENSG00000133872
  • ENST00000545648
  • ENSP00000441351

Symbol
  • TMEM66
  • XTP3
  • XTP3
  • FOAP-7
  • TMEM66
  • HSPC035
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.94
kinase perturbation
0.84
transcription factor perturbation
0.74
tissue
0.68
cell type or tissue
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.34   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.34   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (58)
1 – 10 of 58
CDH5
Tbio
Novelty:  0.00072649
p_int:  0.999653218
p_ni:  0.000345354
p_wrong:  0.000001429
Data Source:  BioPlex
TMEM30A
Tbio
Novelty:  0.05115559
p_int:  0.999559633
p_ni:  0.000419961
p_wrong:  0.000020406
Score:  0.398
Data Source:  BioPlex,STRINGDB
FAF2
Tbio
Novelty:  0.03048598
p_int:  0.999525733
p_ni:  0.000449958
p_wrong:  0.000024309
Score:  0.487
Data Source:  BioPlex,STRINGDB
TEX28
Tdark
Novelty:  0.10581423
p_int:  0.999414628
p_ni:  0.000510855
p_wrong:  0.000074518
Data Source:  BioPlex
ABHD5
Tbio
Family:  Enzyme
Novelty:  0.00806614
p_int:  0.998680851
p_ni:  0.001319147
p_wrong:  1e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
CHRNB1
Tclin
Family:  IC
Novelty:  0.04777051
p_int:  0.997551544
p_ni:  0.002445108
p_wrong:  0.000003348
Data Source:  BioPlex
SLC17A2
Tdark
Family:  Transporter
Novelty:  0.23941275
p_int:  0.997049531
p_ni:  0.002950467
p_wrong:  2e-9
Data Source:  BioPlex
PTCHD3
Tbio
Novelty:  0.00081643
p_int:  0.993275437
p_ni:  0.006722061
p_wrong:  0.000002501
Data Source:  BioPlex
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.991960037
p_ni:  0.005652028
p_wrong:  0.002387936
Data Source:  BioPlex
SYNE4
Tbio
Novelty:  0.0739848
p_int:  0.989629379
p_ni:  0.008153711
p_wrong:  0.00221691
Data Source:  BioPlex
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
1.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
store-operated calcium entry associated regulatory factor
VGNC:10330
464092
Macaque
store-operated calcium entry associated regulatory factor
693452
Mouse
MGI:1915137
67887
Rat
RGD:1303011
290796
Dog
store-operated calcium entry associated regulatory factor
VGNC:45866
482878
Species
Name
OMA
EggNOG
Inparanoid
Chimp
store-operated calcium entry associated regulatory factor
Macaque
store-operated calcium entry associated regulatory factor
Mouse
Rat
Dog
store-operated calcium entry associated regulatory factor
Publication Statistics
PubMed Score 29.34
PubMed score by year
PubTator Score 8.24
PubTator score by year