You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MOAP1
Modulator of apoptosis 1

Protein Summary
Description
Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298894
  • ENSP00000298894
  • ENSG00000165943
  • ENST00000556883
  • ENSP00000451594
  • ENST00000616515
  • ENSP00000482284
  • ENSG00000278268
  • ENST00000627896
  • ENSP00000486260

Symbol
  • PNMA4
  • MAP-1
  • PNMA4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
transcription factor binding site profile
0.86
kinase perturbation
0.84
PubMedID
0.67
transcription factor
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.42   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 303   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.42   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 303   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (33)
1 – 10 of 33
PNMA1
Tbio
Novelty: 0.06899807
p_int: 0.999999542
p_ni: 4.27e-7
p_wrong: 3.1e-8
Score: 0.717
Data Source: BioPlex,STRINGDB
PNMA8A
Tdark
Novelty: 0.95674878
p_int: 0.999993487
p_ni: 0.000006421
p_wrong: 9.2e-8
Score: 0.863
Data Source: BioPlex,STRINGDB
MYO5C
Tbio
Novelty: 0.05680943
p_int: 0.999878842
p_ni: 0.000121158
Score: 0.173
Data Source: BioPlex,STRINGDB
SIRT2
Tchem
Family: Epigenetic
Novelty: 0.00093962
p_int: 0.997619713
p_ni: 0.002379814
p_wrong: 4.74e-7
Score: 0.165
Data Source: BioPlex,STRINGDB
PNMA2
Tbio
Novelty: 0.00162709
p_int: 0.996662251
p_ni: 0.003337749
Score: 0.228
Data Source: BioPlex,STRINGDB
ASPM
Tbio
Novelty: 0.00599688
p_int: 0.955528345
p_ni: 0.044471655
Data Source: BioPlex
MYO9B
Tbio
Novelty: 0.0164265
p_int: 0.901950213
p_ni: 0.098049787
Score: 0.189
Data Source: BioPlex,STRINGDB
RASSF1
Tbio
Novelty: 0.00137149
Score: 0.957
Data Source: STRINGDB
RASSF6
Tbio
Novelty: 0.04940382
Score: 0.743
Data Source: STRINGDB
TRIM39
Tbio
Family: Enzyme
Novelty: 0.0837441
Score: 0.728
Data Source: STRINGDB
Publication Statistics
PubMed Score  26.42

PubMed score by year
PubTator Score  100.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer