Tbio MOAP1 Modulator of apoptosis 1

Protein Summary

Description

Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96BY2
• B2RDF6
• Q9H833
• Q9HAS1
• MAP-1

Gene Name

• MOAP1

Ensembl ID

• ENST00000298894
• ENSP00000298894
• ENSG00000165943
• ENST00000556883
• ENSP00000451594
• ENST00000616515
• ENSP00000482284
• ENSG00000278268
• ENST00000627896
• ENSP00000486260

Symbol

• PNMA4
• MAP-1
• PNMA4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.92
transcription factor binding site profile	0.86
kinase perturbation	0.84
PubMedID	0.67
transcription factor	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.07   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 303   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.07   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 303   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0