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Tbio
MOAP1
Modulator of apoptosis 1

Protein Summary
Description
Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298894
  • ENSP00000298894
  • ENSG00000165943
  • ENST00000556883
  • ENSP00000451594
  • ENST00000616515
  • ENSP00000482284
  • ENSG00000278268
  • ENST00000627896
  • ENSP00000486260

Symbol
  • PNMA4
  • MAP-1
  • PNMA4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
transcription factor binding site profile
0.86
kinase perturbation
0.84
PubMedID
0.67
transcription factor
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.24   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 303   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.24   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 303   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
PNMA1
Tbio
Novelty:  0.06899807
p_int:  0.999999542
p_ni:  4.27e-7
p_wrong:  3.1e-8
Score:  0.717
Data Source:  BioPlex,STRINGDB
PNMA8A
Tdark
Novelty:  0.95674878
p_int:  0.999993487
p_ni:  0.000006421
p_wrong:  9.2e-8
Score:  0.863
Data Source:  BioPlex,STRINGDB
MYO5C
Tbio
Novelty:  0.05680943
p_int:  0.999878842
p_ni:  0.000121158
Score:  0.173
Data Source:  BioPlex,STRINGDB
SIRT2
Tchem
Family:  Epigenetic
Novelty:  0.00093962
p_int:  0.997619713
p_ni:  0.002379814
p_wrong:  4.74e-7
Score:  0.165
Data Source:  BioPlex,STRINGDB
PNMA2
Tbio
Novelty:  0.00162709
p_int:  0.996662251
p_ni:  0.003337749
Score:  0.228
Data Source:  BioPlex,STRINGDB
ASPM
Tbio
Novelty:  0.00599688
p_int:  0.955528345
p_ni:  0.044471655
Data Source:  BioPlex
MYO9B
Tbio
Novelty:  0.0164265
p_int:  0.901950213
p_ni:  0.098049787
Score:  0.189
Data Source:  BioPlex,STRINGDB
RASSF1
Tbio
Novelty:  0.00137149
Score:  0.957
Data Source:  STRINGDB
RASSF6
Tbio
Novelty:  0.04940382
Score:  0.743
Data Source:  STRINGDB
TRIM39
Tbio
Family:  Enzyme
Novelty:  0.0837441
Score:  0.728
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hormone measurement
1
1
1
5.3
hormone measurement
1
1
1
5.3
2
1
0
1
3.9
2
1
0
1
3.9
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hormone measurement
1
5.3
hormone measurement
1
5.3
0
1
3.9
0
1
3.9
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 27.24
PubMed score by year
PubTator Score 100.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title