MOAP1
Modulator of apoptosis 1
Protein Summary
Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008]
- ENST00000298894
- ENSP00000298894
- ENSG00000165943
- ENST00000556883
- ENSP00000451594
- ENST00000616515
- ENSP00000482284
- ENSG00000278268
- ENST00000627896
- ENSP00000486260
- PNMA4
- MAP-1
- PNMA4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.92 | ||
transcription factor binding site profile | 0.86 | ||
kinase perturbation | 0.84 | ||
PubMedID | 0.67 | ||
transcription factor | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.24 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 303 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.24 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 303 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (33)
PNMA1
Novelty: 0.06899807
p_int: 0.999999542
p_ni: 4.27e-7
p_wrong: 3.1e-8
Score: 0.717
Data Source: BioPlex,STRINGDB
PNMA8A
Novelty: 0.95674878
p_int: 0.999993487
p_ni: 0.000006421
p_wrong: 9.2e-8
Score: 0.863
Data Source: BioPlex,STRINGDB
MYO5C
Novelty: 0.05680943
p_int: 0.999878842
p_ni: 0.000121158
Score: 0.173
Data Source: BioPlex,STRINGDB
SIRT2
Family: Epigenetic
Novelty: 0.00093962
p_int: 0.997619713
p_ni: 0.002379814
p_wrong: 4.74e-7
Score: 0.165
Data Source: BioPlex,STRINGDB
PNMA2
Novelty: 0.00162709
p_int: 0.996662251
p_ni: 0.003337749
Score: 0.228
Data Source: BioPlex,STRINGDB
MYO9B
Novelty: 0.0164265
p_int: 0.901950213
p_ni: 0.098049787
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (1)
Components (4)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
hormone measurement | 1 | 1 | 1 | 5.3 | ||||||
hormone measurement | 1 | 1 | 1 | 5.3 | ||||||
2 | 1 | 0 | 1 | 3.9 | ||||||
2 | 1 | 0 | 1 | 3.9 | ||||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hormone measurement | 1 | 5.3 | |||||
hormone measurement | 1 | 5.3 | |||||
0 | 1 | 3.9 | |||||
0 | 1 | 3.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:1915555 | 64113 | ||||||
Rat | RGD:1307230 | 299261 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Publication Statistics
PubMed Score 27.24
PubMed score by year
PubTator Score 100.24
PubTator score by year
Related Publications
Text Mined References (29)
GeneRif Annotations (14)
Items per page:
0 of 0
PMID | Year | Title |
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