You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ALKBH8
Alkylated DNA repair protein alkB homolog 8

Protein Summary
Description
Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260318
  • ENSP00000260318
  • ENSG00000137760
  • ENST00000389568
  • ENSP00000374219
  • ENST00000417449
  • ENSP00000397673
  • ENST00000428149
  • ENSP00000415885
  • ENST00000429370
  • ENSP00000391225

Symbol
  • ABH8
  • ABH8
  • TRM9
  • TRMT9
  • TRMT9A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
transcription factor binding site profile
0.78
histone modification site profile
0.76
protein domain
0.73
microRNA
0.58


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.5   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.5   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alkB homolog 8, tRNA methyltransferase
VGNC:6762
466772
Mouse
MGI:1914917
67667
Rat
RGD:1304687
366783
Dog
alkB homolog 8, tRNA methyltransferase
VGNC:37808
489424
Horse
alkB homolog 8, tRNA methyltransferase
VGNC:15259
100061658
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alkB homolog 8, tRNA methyltransferase
Mouse
Rat
Dog
alkB homolog 8, tRNA methyltransferase
Horse
alkB homolog 8, tRNA methyltransferase
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96BT7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (108)
1 – 10 of 108
TRMT112
Tbio
Family:  Enzyme
Novelty:  0.05451623
Score:  0.994
Data Source:  STRINGDB
ALKBH1
Tbio
Family:  Enzyme
Novelty:  0.00504781
Score:  0.939
Data Source:  STRINGDB
N6AMT1
Tbio
Family:  Enzyme
Novelty:  0.04804276
Score:  0.912
Data Source:  STRINGDB
TRMT11
Tbio
Family:  Enzyme
Novelty:  0.11506701
Score:  0.903
Data Source:  STRINGDB
ALKBH2
Tbio
Family:  Enzyme
Novelty:  0.02318716
Score:  0.894
Data Source:  STRINGDB
CTU1
Tbio
Novelty:  0.04670058
Score:  0.881
Data Source:  STRINGDB
ALKBH4
Tbio
Family:  Enzyme
Novelty:  0.34513259
Score:  0.877
Data Source:  STRINGDB
NSUN2
Tbio
Family:  Enzyme
Novelty:  0.01546947
Score:  0.876
Data Source:  STRINGDB
ELP3
Tbio
Family:  Epigenetic
Novelty:  0.0166061
Score:  0.872
Data Source:  STRINGDB
CTU2
Tdark
Novelty:  0.00936441
Score:  0.867
Data Source:  STRINGDB
Publication Statistics
PubMed Score  35.50

PubMed score by year
PubTator Score  10.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer