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Tbio
TESC
Calcineurin B homologous protein 3

Protein Summary
Description
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335209
  • ENSP00000334785
  • ENSG00000088992
  • ENST00000470612
  • ENSP00000432716
  • ENST00000541210
  • ENSP00000445689

Symbol
  • CHP3
  • TSC
  • CHP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
PubMedID
0.76
transcription factor binding site profile
0.74
molecular function
0.7
small molecule perturbation
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.13   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.13   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
3
85.7
self reported educational attainment
1
1
1
56.5
lifestyle measurement
1
1
1
53
platelet crit
1
1
1
36
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
85.7
self reported educational attainment
1
56.5
lifestyle measurement
1
53
platelet crit
1
36
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tescalcin
VGNC:5618
740872
Macaque
tescalcin
693518
Mouse
MGI:1930803
57816
Rat
RGD:1566317
288689
Dog
tescalcin
VGNC:52973
611331
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tescalcin
Macaque
tescalcin
Mouse
Rat
Dog
tescalcin
Gene Ontology Terms (25)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (33)
1 – 10 of 33
LPAR1
Tchem
Family: GPCR
Novelty: 0.00318056
p_int: 0.999995497
p_ni: 6.59e-7
p_wrong: 0.000003844
Score: 0.516
Data Source: BioPlex,STRINGDB
IPPK
Tbio
Family: Enzyme
Novelty: 0.02169701
p_int: 0.996147873
p_ni: 4.9e-8
p_wrong: 0.003852078
Score: 0.531
Data Source: BioPlex,STRINGDB
SLC9A1
Tchem
Family: Transporter
Novelty: 0.00096678
Score: 0.868
Data Source: STRINGDB
FBXO21
Tbio
Novelty: 0.2186203
Score: 0.668
Data Source: STRINGDB
MAFB
Tbio
Family: TF
Novelty: 0.00646074
Score: 0.641
Data Source: STRINGDB
CRYL1
Tbio
Family: Enzyme
Novelty: 0.04513297
Score: 0.602
Data Source: STRINGDB
NAA10
Tbio
Family: Enzyme
Novelty: 0.00086809
Score: 0.586
Data Source: STRINGDB
SBNO1
Tdark
Novelty: 0.30701767
Score: 0.58
Data Source: STRINGDB
PPP3CA
Tchem
Family: Enzyme
Novelty: 0.00234189
Score: 0.531
Data Source: STRINGDB
SLC9A5
Tchem
Family: Transporter
Novelty: 0.05361766
Score: 0.53
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.13

PubMed score by year
PubTator Score  10.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer