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Tbio
TESC
Calcineurin B homologous protein 3

Protein Summary
Description
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335209
  • ENSP00000334785
  • ENSG00000088992
  • ENST00000470612
  • ENSP00000432716
  • ENST00000541210
  • ENSP00000445689

Symbol
  • CHP3
  • TSC
  • CHP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
PubMedID
0.76
transcription factor binding site profile
0.74
molecular function
0.7
small molecule perturbation
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.56   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.56   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (25)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (33)
1 – 10 of 33
LPAR1
Tchem
Family: GPCR
Novelty: 0.004102
p_int: 0.999995497
p_ni: 6.59e-7
p_wrong: 0.000003844
Score: 0.516
Data Source: BioPlex,STRINGDB
IPPK
Tbio
Family: Enzyme
Novelty: 0.04063664
p_int: 0.996147873
p_ni: 4.9e-8
p_wrong: 0.003852078
Score: 0.531
Data Source: BioPlex,STRINGDB
SLC9A1
Tchem
Family: Transporter
Novelty: 0.00112175
Score: 0.868
Data Source: STRINGDB
FBXO21
Tbio
Novelty: 0.46632124
Score: 0.668
Data Source: STRINGDB
MAFB
Tbio
Family: TF
Novelty: 0.00869998
Score: 0.641
Data Source: STRINGDB
CRYL1
Tbio
Family: Enzyme
Novelty: 0.02941898
Score: 0.602
Data Source: STRINGDB
NAA10
Tbio
Family: Enzyme
Novelty: 0.00344069
Score: 0.586
Data Source: STRINGDB
SBNO1
Tdark
Novelty: 0.86387435
Score: 0.58
Data Source: STRINGDB
PPP3CA
Tchem
Family: Enzyme
Novelty: 0.00238194
Score: 0.531
Data Source: STRINGDB
SLC9A5
Tchem
Family: Transporter
Novelty: 0.0667815
Score: 0.53
Data Source: STRINGDB
Publication Statistics
PubMed Score  21.56

PubMed score by year
PubTator Score  10.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer