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Tchem
SGK3
Serine/threonine-protein kinase Sgk3

Protein Classes
Protein Summary
Description
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345714
  • ENSP00000331816
  • ENSG00000104205
  • ENST00000396596
  • ENSP00000379842
  • ENST00000519289
  • ENSP00000429022
  • ENST00000520976
  • ENSP00000430691
  • ENST00000521198
  • ENSP00000430463
  • ENST00000522398
  • ENSP00000430256

Symbol
  • CISK
  • SGKL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
interacting protein
0.86
transcription factor
0.77
PubMedID
0.73
microRNA
0.71


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.43   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 312   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.43   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
3
17
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
3
17
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96BR1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (170)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Gene Ontology Terms (20)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (71)
1 – 10 of 71
CD79B
Tclin
Novelty: 0.00227414
p_int: 0.981106823
p_ni: 0.018260578
p_wrong: 0.000632599
Data Source: BioPlex
ICAM1
Tchem
Novelty: 0.00009746
p_int: 0.847265519
p_ni: 0.012914778
p_wrong: 0.139819703
Data Source: BioPlex
PDPK1
Tchem
Family: Kinase
Novelty: 0.00430458
Score: 0.922
Data Source: STRINGDB
MTOR
Tclin
Family: Kinase
Novelty: 0.00012333
Score: 0.859
Data Source: STRINGDB
FOXO3
Tbio
Family: TF
Novelty: 0.00074316
Score: 0.833
Data Source: STRINGDB
PIKFYVE
Tchem
Family: Kinase
Novelty: 0.00441336
Score: 0.815
Data Source: STRINGDB
SGK1
Tchem
Family: Kinase
Novelty: 0.00155681
Score: 0.814
Data Source: STRINGDB
SGK2
Tchem
Family: Kinase
Novelty: 0.06488042
Score: 0.813
Data Source: STRINGDB
FOXO1
Tbio
Family: TF
Novelty: 0.00058938
Score: 0.717
Data Source: STRINGDB
PIK3CA
Tclin
Family: Kinase
Novelty: 0.00044273
Score: 0.682
Data Source: STRINGDB
Publication Statistics
PubMed Score  40.43

PubMed score by year
PubTator Score  1.05

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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