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Tbio
PPWD1
Peptidylprolyl isomerase domain and WD repeat-containing protein 1

Protein Classes
Protein Summary
Description
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be involved in pre-mRNA splicing (PubMed:11991638).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261308
  • ENSP00000261308
  • ENSG00000113593
  • ENST00000538977
  • ENSP00000444496

Symbol
  • KIAA0073
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
tissue sample
0.75
protein domain
0.73
disease perturbation
0.62
cell type or tissue
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.53   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.53   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase domain and WD repeat containing 1
VGNC:4135
743348
Macaque
peptidylprolyl isomerase domain and WD repeat containing 1
696267
Mouse
MGI:2443069
238831
Rat
RGD:1310204
294711
Dog
peptidylprolyl isomerase domain and WD repeat containing 1
VGNC:44932
478078
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase domain and WD repeat containing 1
Macaque
peptidylprolyl isomerase domain and WD repeat containing 1
Mouse
Rat
Dog
peptidylprolyl isomerase domain and WD repeat containing 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96BP3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Protein-Protein Interactions (203)
1 – 10 of 203
SEC13
Tbio
Novelty: 0.00709413
p_int: 0.999992429
p_ni: 0.000007571
Score: 0.243
Data Source: BioPlex,STRINGDB
ZNF232
Tdark
Family: TF
Novelty: 0.68288358
p_int: 0.994103147
p_ni: 0.000213293
p_wrong: 0.00568356
Score: 0.195
Data Source: BioPlex,STRINGDB
ZMYM6
Tdark
Novelty: 0.4933879
p_int: 0.993304155
p_ni: 0.005230929
p_wrong: 0.001464916
Data Source: BioPlex
DHX16
Tbio
Family: Enzyme
Novelty: 0.02678951
Score: 0.955
Data Source: STRINGDB
CWC27
Tbio
Family: Enzyme
Novelty: 0.15135654
Score: 0.952
Data Source: STRINGDB
XAB2
Tbio
Novelty: 0.04104647
Score: 0.947
Data Source: STRINGDB
CDC40
Tbio
Novelty: 0.03139044
Score: 0.944
Data Source: STRINGDB
SF3A2
Tbio
Novelty: 0.03658692
Score: 0.942
Data Source: STRINGDB
PPIL4
Tdark
Family: Enzyme
Novelty: 0.3737992
Score: 0.941
Data Source: STRINGDB
CWC25
Tdark
Novelty: 0.13727856
Score: 0.94
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.53

PubMed score by year
PubTator Score  2.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer