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Tbio
PPWD1
Peptidylprolyl isomerase domain and WD repeat-containing protein 1

Protein Summary
Description
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be involved in pre-mRNA splicing (PubMed:11991638).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261308
  • ENSP00000261308
  • ENSG00000113593
  • ENST00000538977
  • ENSP00000444496

Symbol
  • KIAA0073
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
tissue sample
0.75
protein domain
0.73
disease perturbation
0.62
cell type or tissue
0.58


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.53   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.53   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (203)
SEC13
Tbio
Novelty:  0.00709413
p_int:  0.999992429
p_ni:  0.000007571
Score:  0.243
Data Source:  BioPlex,STRINGDB
ZNF232
Tdark
Family:  TF
Novelty:  0.68288358
p_int:  0.994103147
p_ni:  0.000213293
p_wrong:  0.00568356
Score:  0.195
Data Source:  BioPlex,STRINGDB
ZMYM6
Tdark
Novelty:  0.4933879
p_int:  0.993304155
p_ni:  0.005230929
p_wrong:  0.001464916
Data Source:  BioPlex
DHX16
Tbio
Family:  Enzyme
Novelty:  0.02678951
Score:  0.955
Data Source:  STRINGDB
CWC27
Tbio
Family:  Enzyme
Novelty:  0.15135654
Score:  0.952
Data Source:  STRINGDB
XAB2
Tbio
Novelty:  0.04104647
Score:  0.947
Data Source:  STRINGDB
CDC40
Tbio
Novelty:  0.03139044
Score:  0.944
Data Source:  STRINGDB
SF3A2
Tbio
Novelty:  0.03658692
Score:  0.942
Data Source:  STRINGDB
PPIL4
Tdark
Family:  Enzyme
Novelty:  0.3737992
Score:  0.941
Data Source:  STRINGDB
CWC25
Tdark
Novelty:  0.13727856
Score:  0.94
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
feeling tense measurement
1
1
0
6
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
feeling tense measurement
0
6
31.4
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase domain and WD repeat containing 1
VGNC:4135
743348
Macaque
peptidylprolyl isomerase domain and WD repeat containing 1
696267
Mouse
MGI:2443069
238831
Rat
RGD:1310204
294711
Dog
peptidylprolyl isomerase domain and WD repeat containing 1
VGNC:44932
478078
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase domain and WD repeat containing 1
Macaque
peptidylprolyl isomerase domain and WD repeat containing 1
Mouse
Rat
Dog
peptidylprolyl isomerase domain and WD repeat containing 1
Publication Statistics
PubMed Score 8.53
PubMed score by year
PubTator Score 2.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title