Tbio PPWD1 Peptidylprolyl isomerase domain and WD repeat-containing protein 1

Protein Summary

Description

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be involved in pre-mRNA splicing (PubMed:11991638).

Uniprot Accession IDs

• Q96BP3
• B4DWR9
• Q15002
• Q7KZ89

Gene Name

• PPWD1

Ensembl ID

• ENST00000261308
• ENSP00000261308
• ENSG00000113593
• ENST00000538977
• ENSP00000444496

Symbol

• KIAA0073

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
tissue sample	0.75
protein domain	0.73
disease perturbation	0.62
cell type or tissue	0.58

Protein Classes

PANTHER Classes

Protein / Isomerase / Peptidylprolyl Isomerase Domain And Wd Repeat-containing Protein 1

DTO Classes

Protein / Enzyme / Isomerase / Peptidylprolyl Isomerase Domain And Wd Repeat-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.65   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 186   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.65   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0