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Tbio
OTULIN
Ubiquitin thioesterase otulin

Protein Summary
Description
Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:26997266, PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:27523608, PubMed:27559085, PubMed:24726323, PubMed:24726327, PubMed:28919039). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (PubMed:23746843, PubMed:23806334). OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PubMed:26670046). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608). In myeloid ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284274
  • ENSP00000284274
  • ENSG00000154124

Symbol
  • FAM105B
  • GUM
  • AIPDS
  • FAM105B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
microRNA
0.76
transcription factor perturbation
0.74
histone modification site profile
0.71
cell type or tissue
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.06   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.06   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Eczema
2
1
0
1.1
20.9
2
1
0
1.1
20.9
1
1
0
1.1
15.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Eczema
0
1.1
20.9
0
1.1
20.9
0
1.1
15.6
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Death Receptor Signalling (R-HSA-73887)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Death Receptor Signalling
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Protein ubiquitination
Reactome
Regulation of TNFR1 signaling
Name
Explore in Pharos
Explore in Source
Death Receptor Signalling
Metabolism of proteins
Post-translational protein modification
Protein ubiquitination
Regulation of TNFR1 signaling
Protein-Protein Interactions (77)
1 – 10 of 77
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
p_int: 0.997910527
p_ni: 0.00208935
p_wrong: 1.23e-7
Data Source: BioPlex
KLRC4
Tbio
Novelty: 0.16922525
p_int: 0.996297577
p_ni: 0.003701235
p_wrong: 0.000001188
Data Source: BioPlex
PDZK1P1
Tdark
p_int: 0.996110756
p_ni: 0.003270735
p_wrong: 0.000618509
Data Source: BioPlex
LAMP2
Tbio
Novelty: 0.00168009
p_int: 0.99313053
p_ni: 0.00686947
Data Source: BioPlex
SLC18A1
Tchem
Family: Transporter
Novelty: 0.01135292
p_int: 0.990370688
p_ni: 0.008834145
p_wrong: 0.000795167
Data Source: BioPlex
SYNJ2BP
Tbio
Novelty: 0.02520087
p_int: 0.99017718
p_ni: 0.008909154
p_wrong: 0.000913666
Data Source: BioPlex
VIPR2
Tchem
Family: GPCR
Novelty: 0.00463802
p_int: 0.977797981
p_ni: 0.022096019
p_wrong: 0.000106001
Data Source: BioPlex
ICAM1
Tchem
Novelty: 0.00009746
p_int: 0.970101206
p_ni: 0.028299955
p_wrong: 0.001598839
Data Source: BioPlex
B3GALT5
Tbio
Family: Enzyme
Novelty: 0.04158039
p_int: 0.963393061
p_ni: 0.036236011
p_wrong: 0.000370928
Data Source: BioPlex
SLC2A9
Tbio
Family: Transporter
Novelty: 0.00683926
p_int: 0.947453615
p_ni: 0.052090577
p_wrong: 0.000455808
Data Source: BioPlex
Publication Statistics
PubMed Score  27.06

PubMed score by year
PubTator Score  22.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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