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Tbio
ARL8A
ADP-ribosylation factor-like protein 8A

Protein Summary
Description
May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272217
  • ENSP00000272217
  • ENSG00000143862

Symbol
  • ARL10B
  • GIE2
  • GIE2
  • ARL10B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
interacting protein
0.87
kinase perturbation
0.76
transcription factor perturbation
0.74
cellular component
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.78   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.78   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (116)
1 – 10 of 116
SPG21
Tbio
Family:  Enzyme
Novelty:  0.07929043
p_int:  0.999999713
p_ni:  1.7e-7
p_wrong:  1.17e-7
Data Source:  BioPlex
ARL8B
Tbio
Family:  Enzyme
Novelty:  0.06939851
p_int:  0.999999484
p_ni:  7.9e-8
p_wrong:  4.36e-7
Data Source:  BioPlex
RDH14
Tdark
Family:  Enzyme
Novelty:  0.35816611
p_int:  0.999994152
p_ni:  0.000005848
Data Source:  BioPlex
TKFC
Tbio
Family:  Enzyme
Novelty:  0.00380602
p_int:  0.999963172
p_ni:  0.000036495
p_wrong:  3.33e-7
Data Source:  BioPlex
DNAJC13
Tbio
Novelty:  0.03251995
p_int:  0.999679483
p_ni:  0.000320517
Score:  0.906
Data Source:  BioPlex,STRINGDB
ATRIP
Tbio
Novelty:  0.01415267
p_int:  0.998626595
p_ni:  0.001372899
p_wrong:  5.06e-7
Data Source:  BioPlex
TBC1D9B
Tdark
Novelty:  0.66719861
p_int:  0.99574261
p_ni:  0.004257374
p_wrong:  1.6e-8
Score:  0.199
Data Source:  BioPlex,STRINGDB
MOCOS
Tbio
Family:  Enzyme
Novelty:  0.05022905
p_int:  0.99253642
p_ni:  0.007463548
p_wrong:  3.2e-8
Data Source:  BioPlex
DHRS3
Tbio
Family:  Enzyme
Novelty:  0.04448013
p_int:  0.989363745
p_ni:  0.001701059
p_wrong:  0.008935196
Data Source:  BioPlex
TBC1D9
Tbio
Novelty:  0.20059899
p_int:  0.964812301
p_ni:  0.024502918
p_wrong:  0.010684781
Score:  0.208
Data Source:  BioPlex,STRINGDB
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (19)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
70.8
2
2
0
1.1
65.7
body mass index
1
1
1
57.8
heel bone mineral density
2
3
3
55.2
mean corpuscular volume
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
70.8
0
1.1
65.7
body mass index
1
57.8
heel bone mineral density
3
55.2
mean corpuscular volume
1
53.7
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1915974
68724
Rat
RGD:1565940
498234
Chicken
ADP ribosylation factor like GTPase 8A
CGNC:375
421175
Anole lizard
ADP ribosylation factor like GTPase 8A
100566871
Xenopus
ADP ribosylation factor like GTPase 8A
XB-GENE-866659
394587
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Chicken
ADP ribosylation factor like GTPase 8A
Anole lizard
ADP ribosylation factor like GTPase 8A
Xenopus
ADP ribosylation factor like GTPase 8A
Publication Statistics
PubMed Score 6.78
PubMed score by year
PubTator Score 2.17
PubTator score by year