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Tbio
ELMO3
Engulfment and cell motility protein 3

Protein Classes
Protein Summary
Description
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393997
  • ENSP00000377566
  • ENSG00000102890
  • ENST00000477898
  • ENSP00000458539

Symbol
  • CED12
  • CED-12
  • ELMO-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.85
virus perturbation
0.79
protein domain
0.73
gene perturbation
0.51
tissue sample
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.75   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.75   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
4
4
96.2
mean reticulocyte volume
1
4
4
94.2
heel bone mineral density
3
3
6
93.1
BMI-adjusted waist circumference
4
4
7
64.4
high density lipoprotein cholesterol measurement
2
2
2
62.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
96.2
mean reticulocyte volume
4
94.2
heel bone mineral density
6
93.1
BMI-adjusted waist circumference
7
64.4
high density lipoprotein cholesterol measurement
2
62.6
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
engulfment and cell motility 3
VGNC:5756
454159
Macaque
engulfment and cell motility 3
698664
Mouse
MGI:2679007
234683
Rat
RGD:1304734
291962
Dog
engulfment and cell motility 3
VGNC:40311
489763
Species
Name
OMA
EggNOG
Inparanoid
Chimp
engulfment and cell motility 3
Macaque
engulfment and cell motility 3
Mouse
Rat
Dog
engulfment and cell motility 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96BJ8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (45)
1 – 10 of 45
DOCK1
Tbio
Novelty:  0.00867391
p_int:  0.999999971
p_ni:  2.8e-8
p_wrong:  1e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
DOCK3
Tbio
Novelty:  0.02190804
p_int:  0.999999964
p_ni:  3.6e-8
p_wrong:  1e-9
Score:  0.969
Data Source:  BioPlex,STRINGDB
DOCK5
Tbio
Novelty:  0.03153692
p_int:  0.999998063
p_ni:  0.000001936
p_wrong:  1e-9
Score:  0.792
Data Source:  BioPlex,STRINGDB
DOCK4
Tbio
Novelty:  0.02356655
p_int:  0.999996196
p_ni:  0.000003782
p_wrong:  2.3e-8
Score:  0.917
Data Source:  BioPlex,STRINGDB
ELMO2
Tbio
Novelty:  0.04258272
p_int:  0.99995251
p_ni:  0.00004749
Score:  0.973
Data Source:  BioPlex,STRINGDB
ELMO1
Tbio
Novelty:  0.01598587
p_int:  0.999817365
p_ni:  0.000177526
p_wrong:  0.000005109
Score:  0.986
Data Source:  BioPlex,STRINGDB
RHOG
Tbio
Family:  Enzyme
Novelty:  0.00412327
Score:  0.93
Data Source:  STRINGDB
GULP1
Tbio
Novelty:  0.01367525
Score:  0.903
Data Source:  STRINGDB
WDR35
Tbio
Novelty:  0.02958717
Score:  0.902
Data Source:  STRINGDB
CRK
Tchem
Novelty:  0.00238512
Score:  0.872
Data Source:  STRINGDB
Publication Statistics
PubMed Score  17.75

PubMed score by year
PubTator Score  10.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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