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Tbio
AIDA
Axin interactor, dorsalization-associated protein

Protein Summary
Description
Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340020
  • ENSP00000339161
  • ENSG00000186063
  • ENST00000355727
  • ENSP00000347964

Symbol
  • C1orf80
  • C1orf80
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.8
histone modification site profile
0.72
interacting protein
0.71
disease perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.22   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.22   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
5
4
1.1
97.2
4
3
0
1.1
90.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
97.2
0
1.1
90.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
axin interactor, dorsalization associated
VGNC:59
457759
Macaque
axin interactor, dorsalization associated
704518
Mouse
MGI:1919737
108909
Rat
RGD:1592746
682999
Dog
axin interactor, dorsalization associated
VGNC:37734
607802
Species
Name
OMA
EggNOG
Inparanoid
Chimp
axin interactor, dorsalization associated
Macaque
axin interactor, dorsalization associated
Mouse
Rat
Dog
axin interactor, dorsalization associated
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96BJ3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (19)
1 – 10 of 19
TMEM185A
Tdark
Novelty:  0.0262898
p_int:  0.999941113
p_ni:  0.000045657
p_wrong:  0.00001323
Data Source:  BioPlex
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.999876813
p_ni:  0.000123187
Data Source:  BioPlex
FSD1
Tbio
Novelty:  0.03452477
p_int:  0.9986703
p_ni:  0.001308298
p_wrong:  0.000021402
Score:  0.183
Data Source:  BioPlex,STRINGDB
NFKBIA
Tchem
Novelty:  0.00022873
p_int:  0.9986703
p_ni:  0.001308298
p_wrong:  0.000021402
Score:  0.177
Data Source:  BioPlex,STRINGDB
TNFAIP3
Tbio
Novelty:  0.00257088
p_int:  0.957896381
p_ni:  0.013190803
p_wrong:  0.028912816
Score:  0.188
Data Source:  BioPlex,STRINGDB
EMSY
Tbio
Novelty:  0.02216272
Score:  0.8
Data Source:  STRINGDB
DCAF7
Tbio
Novelty:  0.02609518
Score:  0.62
Data Source:  STRINGDB
PAGE2B
Tdark
Novelty:  0.70952249
Score:  0.552
Data Source:  STRINGDB
RPL36A
Tbio
Novelty:  0.06115838
Score:  0.544
Data Source:  STRINGDB
GRM8
Tchem
Family:  GPCR
Novelty:  0.00827879
Score:  0.525
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1.22

PubMed score by year
PubTator Score  163.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer