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Tbio
TMIGD2
Transmembrane and immunoglobulin domain-containing protein 2

Protein Summary
Description
Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301272
  • ENSP00000301272
  • ENSG00000167664
  • ENST00000595645
  • ENSP00000470561

Symbol
  • CD28H
  • IGPR1
  • CD28H
  • IGPR1
  • IGPR-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.88
gene perturbation
0.47
biological process
0.43
tissue sample
0.42
protein domain
0.41


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.5   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.5   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane and immunoglobulin domain containing 2
VGNC:13096
737728
Horse
transmembrane and immunoglobulin domain containing 2
VGNC:52029
100062939
Cow
transmembrane and immunoglobulin domain containing 2
VGNC:36133
524354
Pig
transmembrane and immunoglobulin domain containing 2
102164394
Opossum
transmembrane and immunoglobulin domain containing 2
103093802
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane and immunoglobulin domain containing 2
Horse
transmembrane and immunoglobulin domain containing 2
Cow
transmembrane and immunoglobulin domain containing 2
Pig
transmembrane and immunoglobulin domain containing 2
Opossum
transmembrane and immunoglobulin domain containing 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96BF3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (16)
1 – 10 of 16
HHLA2
Tbio
Novelty: 0.06299917
Score: 0.787
Data Source: STRINGDB
NCKIPSD
Tbio
Novelty: 0.07453111
Score: 0.654
Data Source: STRINGDB
CTLA4
Tclin
Novelty: 0.00012781
Score: 0.641
Data Source: STRINGDB
TMIGD1
Tbio
Novelty: 0.21889871
Score: 0.638
Data Source: STRINGDB
ICOS
Tbio
Novelty: 0.01378323
Score: 0.622
Data Source: STRINGDB
CD80
Tclin
Novelty: 0.00031181
Score: 0.559
Data Source: STRINGDB
CD86
Tclin
Novelty: 0.00029965
Score: 0.551
Data Source: STRINGDB
CD28
Tbio
Novelty: 0.00036482
Score: 0.504
Data Source: STRINGDB
ICOSLG
Tbio
Novelty: 0.00693966
Score: 0.475
Data Source: STRINGDB
PDCD1LG2
Tbio
Novelty: 0.00188515
Score: 0.473
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.50

PubMed score by year
PubTator Score  5.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer