Tbio SKA1 Spindle and kinetochore-associated protein 1

Protein Summary

Description

Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). In the complex, it mediates the interaction with microtubules (PubMed:19289083, PubMed:23085020).

Uniprot Accession IDs

• Q96BD8
• B2R9Y6
• B4E0P4

Gene Name

• SKA1

Ensembl ID

• ENST00000285116
• ENSP00000285116
• ENSG00000154839
• ENST00000398452
• ENSP00000381470
• ENST00000417656
• ENSP00000397222
• ENST00000571751
• ENSP00000458992
• ENSG00000262634
• ENST00000616604
• ENSP00000478259
• ENST00000633940
• ENSP00000488815

Symbol

• C18orf24
• C18orf24

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
kinase perturbation	0.88
transcription factor perturbation	0.61
small molecule perturbation	0.6
cellular component	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.48   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 84   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.48   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0