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Tbio
PHF21A
PHD finger protein 21A

Protein Summary
Description
Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323180
  • ENSP00000323152
  • ENSG00000135365
  • ENST00000418153
  • ENSP00000398824

Symbol
  • BHC80
  • KIAA1696
  • BHC80
  • BM-006
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
kinase perturbation
0.91
disease perturbation
0.83
transcription factor binding site profile
0.78
cell type or tissue
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.7   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.7   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
4
4
96
self reported educational attainment
1
1
1
81.1
venous thromboembolism
1
2
2
75.8
smoking status measurement
2
2
1
1
75.5
mathematical ability
1
1
1
65.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
96
self reported educational attainment
1
81.1
venous thromboembolism
2
75.8
smoking status measurement
1
1
75.5
mathematical ability
1
65.5
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
HDACs deacetylate histones
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Factors involved in megakaryocyte development and platelet production
HDACs deacetylate histones
Hemostasis
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (186)
1 – 10 of 186
HMG20A
Tbio
Family: TF
Novelty: 0.11994252
p_int: 0.999999993
p_ni: 7e-9
Score: 0.885
Data Source: BioPlex,STRINGDB
HMG20B
Tbio
Family: TF
Novelty: 0.05983143
p_int: 0.999999914
p_ni: 8.6e-8
Score: 0.996
Data Source: BioPlex,STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
p_int: 0.999995624
p_ni: 0.000004375
p_wrong: 1e-9
Score: 0.978
Data Source: BioPlex,STRINGDB
EXOC1
Tbio
Novelty: 0.01073858
p_int: 0.999931948
p_ni: 0.000068051
p_wrong: 1e-9
Score: 0.153
Data Source: BioPlex,STRINGDB
NUP62
Tbio
Novelty: 0.01432724
p_int: 0.999897975
p_ni: 0.000101996
p_wrong: 2.9e-8
Data Source: BioPlex
RCOR1
Tbio
Family: TF
Novelty: 0.00644648
Score: 0.993
Data Source: STRINGDB
KDM1A
Tchem
Family: Epigenetic
Novelty: 0.00142673
Score: 0.98
Data Source: STRINGDB
HDAC2
Tclin
Family: Epigenetic
Novelty: 0.0011024
Score: 0.962
Data Source: STRINGDB
ING2
Tbio
Family: Epigenetic
Novelty: 0.02424031
Score: 0.958
Data Source: STRINGDB
MORF4L1
Tbio
Family: Epigenetic
Novelty: 0.01696001
Score: 0.937
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.70

PubMed score by year
PubTator Score  6.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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