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Tbio
SLCO4A1
Solute carrier organic anion transporter family member 4A1

Protein Classes
Protein Summary
Description
Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217159
  • ENSP00000217159
  • ENSG00000101187
  • ENST00000370507
  • ENSP00000359538

Symbol
  • OATP1
  • OATP4A1
  • OATPE
  • SLC21A12
  • POAT
  • OATP1
  • OATPE
  • OATP-E
  • OATP4A1
  • OATPRP1
  • SLC21A12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
transcription factor perturbation
0.91
PubMedID
0.8
kinase perturbation
0.76
tissue
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.39   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.39   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of organic anions
Reactome
Transport of small molecules
Reactome
Transport of vitamins, nucleosides, and related molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Transport of organic anions
Transport of small molecules
Transport of vitamins, nucleosides, and related molecules
Protein-Protein Interactions (46)
1 – 10 of 46
SLC10A1
Tchem
Family: Transporter
Novelty: 0.0017924
Score: 0.775
Data Source: STRINGDB
SLC7A13
Tdark
Family: Transporter
Novelty: 0.1422516
Score: 0.688
Data Source: STRINGDB
DLGAP4
Tbio
Novelty: 0.08799804
Score: 0.666
Data Source: STRINGDB
SLC22A8
Tclin
Family: Transporter
Novelty: 0.00363451
Score: 0.651
Data Source: STRINGDB
ABCB11
Tchem
Family: Transporter
Novelty: 0.00136209
Score: 0.643
Data Source: STRINGDB
ABCC3
Tbio
Family: Transporter
Novelty: 0.00323972
Score: 0.634
Data Source: STRINGDB
SLC22A11
Tclin
Family: Transporter
Novelty: 0.01776292
Score: 0.62
Data Source: STRINGDB
SLC16A10
Tbio
Family: Transporter
Novelty: 0.03767726
Score: 0.608
Data Source: STRINGDB
SLC22A9
Tbio
Family: Transporter
Novelty: 0.02803169
Score: 0.607
Data Source: STRINGDB
SLC22A7
Tbio
Family: Transporter
Novelty: 0.00686998
Score: 0.605
Data Source: STRINGDB
Publication Statistics
PubMed Score  45.39

PubMed score by year
PubTator Score  18.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer