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Tbio
SH3KBP1
SH3 domain-containing kinase-binding protein 1

Protein Summary
Description
Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cont ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379698
  • ENSP00000369020
  • ENSG00000147010
  • ENST00000379716
  • ENSP00000369039
  • ENST00000397821
  • ENSP00000380921

Symbol
  • CIN85
  • HSB1
  • CIN85
  • GIG10
  • HSB-1
  • MIG18
  • CD2BP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
hub protein
0.97
small molecule perturbation
0.96
histone modification site profile
0.77
kinase perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.18   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.18   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (279)
CAPZA2
Tbio
Novelty:  0.14014918
p_int:  1
Score:  0.675
Data Source:  BioPlex,STRINGDB
RTKN2
Tbio
Novelty:  0.15149638
p_int:  1
Score:  0.245
Data Source:  BioPlex,STRINGDB
MDC1
Tbio
Novelty:  0.00533097
p_int:  1
Score:  0.188
Data Source:  BioPlex,STRINGDB
SH3BP1
Tbio
Novelty:  8.50014339
p_int:  0.999999995
p_ni:  1e-9
p_wrong:  4e-9
Score:  0.821
Data Source:  BioPlex,STRINGDB
ASAP2
Tbio
Novelty:  0.02744569
p_int:  0.999999992
p_ni:  8e-9
Score:  0.61
Data Source:  BioPlex,STRINGDB
ARAP1
Tbio
Novelty:  0.0479494
p_int:  0.99999999
p_ni:  3e-9
p_wrong:  7e-9
Score:  0.83
Data Source:  BioPlex,STRINGDB
MICALL1
Tbio
Novelty:  0.10288314
p_int:  0.999999989
p_ni:  1e-9
p_wrong:  1e-8
Score:  0.176
Data Source:  BioPlex,STRINGDB
ASAP1
Tbio
Novelty:  0.00913771
p_int:  0.999999981
p_ni:  1.6e-8
p_wrong:  3e-9
Score:  0.586
Data Source:  BioPlex,STRINGDB
STAP1
Tbio
Novelty:  0.17498048
p_int:  0.999999965
p_ni:  3.5e-8
p_wrong:  1e-9
Score:  0.891
Data Source:  BioPlex,STRINGDB
SH3D19
Tbio
Novelty:  0.05352867
p_int:  0.999999828
p_ni:  1.68e-7
p_wrong:  3e-9
Score:  0.249
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
1 – 5 of 6
PDGFRA
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
EGFR
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
IGF1R
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
FGFR3
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
FGFR2
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
Pathways (27)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
Axon guidance
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Axon guidance
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
1
1
1
53.6
total blood protein measurement
1
1
1
51
platelet count
2
2
2
40.1
hematocrit
2
2
2
39.3
hemoglobin measurement
2
2
2
34.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
1
53.6
total blood protein measurement
1
51
platelet count
2
40.1
hematocrit
2
39.3
hemoglobin measurement
2
34.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SH3 domain containing kinase binding protein 1
694764
Mouse
MGI:1889583
58194
Rat
RGD:620904
84357
Dog
SH3 domain containing kinase binding protein 1
VGNC:46129
612797
Horse
SH3 domain containing kinase binding protein 1
VGNC:22944
100058644
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SH3 domain containing kinase binding protein 1
Mouse
Rat
Dog
SH3 domain containing kinase binding protein 1
Horse
SH3 domain containing kinase binding protein 1
Publication Statistics
PubMed Score 83.18
PubMed score by year
PubTator Score 57.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title