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Tbio
CLDN23
Claudin-23

Protein Summary
Description
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in germinal center B-cells, placenta and stomach as well as in colon tumor. This gene is down-regulated in intestinal type gastric cancer. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000519106
  • ENSP00000428780
  • ENSG00000253958
  • ENST00000644143
  • ENSP00000495091
  • ENSG00000285098

Symbol
  • CLDNL
  • hCG1646163
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.78
PubMedID
0.7
transcription factor binding site profile
0.66
gene perturbation
0.63
tissue
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.53   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.53   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
1
1
1
6.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
1
6.2
Pathways (9)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Tight junction interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Tight junction interactions
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (34)
1 – 10 of 34
CLDN12
Tbio
Novelty: 0.04404633
Score: 0.952
Data Source: STRINGDB
CLDN18
Tbio
Novelty: 0.01299528
Score: 0.95
Data Source: STRINGDB
CLDN11
Tbio
Novelty: 0.00275436
Score: 0.947
Data Source: STRINGDB
CLDN10
Tbio
Novelty: 0.02175843
Score: 0.947
Data Source: STRINGDB
CLDN16
Tbio
Novelty: 0.0092505
Score: 0.942
Data Source: STRINGDB
CLDN20
Tdark
Novelty: 0.50330636
Score: 0.936
Data Source: STRINGDB
CLDN5
Tbio
Novelty: 0.00174396
Score: 0.934
Data Source: STRINGDB
MFHAS1
Tbio
Novelty: 0.07577377
Score: 0.93
Data Source: STRINGDB
CLDN4
Tbio
Novelty: 0.00227337
Score: 0.93
Data Source: STRINGDB
CLDN7
Tbio
Novelty: 0.00722366
Score: 0.927
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.53

PubMed score by year
PubTator Score  6.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer