Tbio DACT3 Dapper homolog 3

Protein Summary

Description

May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins.

Uniprot Accession IDs

• Q96B18

Gene Name

• DACT3

Ensembl ID

• ENST00000391916
• ENSP00000375783
• ENSG00000197380

Symbol

• RRR1
• RRR1
• DAPPER3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.8
transcription factor binding site profile	0.64
biological process	0.54
tissue sample	0.53
cell line	0.49

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.76   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 194   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.76   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Gene Ontology Terms (12)

Functions (5)

Components (1)

Processes (6)

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
beta-catenin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
delta-catenin binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
protein kinase A binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
protein kinase C binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
identical protein binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (21)

Explore Interacting Targets

1 – 10 of 21

• See Interactions on String-DB

SESTD1

Tbio

Novelty: 0.1805301

p_int: 0.999999989

p_ni: 9e-9

p_wrong: 2e-9

Score: 0.252

Data Source: BioPlex,STRINGDB

TRAT1

Tbio

Novelty: 0.00064556

p_int: 0.999994706

p_ni: 0.000003851

p_wrong: 0.000001443

Data Source: BioPlex

IFT22

Tdark

Family: Enzyme

Novelty: 0.48997773

p_int: 0.997068989

p_ni: 0.002930959

p_wrong: 5.2e-8

Data Source: BioPlex

PKD2

Tchem

Family: IC

Novelty: 0.00208049

p_int: 0.954108415

p_ni: 0.045891403

p_wrong: 1.83e-7

Data Source: BioPlex

SLC38A2

Tbio

Family: Transporter

Novelty: 0.01178113

p_int: 0.786307522

p_ni: 0.213692477

p_wrong: 2e-9

Data Source: BioPlex

DACT2

Tbio

Novelty: 0.06119733

Score: 0.867

Data Source: STRINGDB

RRS1

Tbio

Novelty: 0.00929224

Score: 0.789

Data Source: STRINGDB

GNG8

Tdark

Novelty: 0.00694874

Score: 0.633

Data Source: STRINGDB

DVL1

Tchem

Novelty: 0.00460899

Score: 0.53

Data Source: STRINGDB

RCCD1

Tbio

Novelty: 0.10479042

Score: 0.525

Data Source: STRINGDB

Publication Statistics

PubMed Score  66.76

PubMed score by year

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PubTator Score  153.17

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MIRAFSFPVSPERGRLRGWLEGSLAGLCELHWLRERQEYRVQQALRLAQPGMGGAEAEDEEDADEDEDAA

1-70

AARRAAAALEEQLEALPGLVWDLGQQLGDLSLESGGLEQESGRSSGFYEDPSSTGGPDSPPSTFCGDSGF

70-140

SGSSSYGRLGPSEPRGIYASERPKSLGDASPSAPEVVGARAAVPRSFSAPYPTAGGSAGPEACSSAERRA

140-210

RAGPFLTPSPLHAVAMRSPRPCGRPPTDSPDAGGAGRPLDGYISALLRRRRRRGAGQPRTSPGGADGGPR

210-280

RQNSVRQRPPDASPSPGSARPAREPSLERVGGHPTSPAALSRAWASSWESEAAPEPAAPPAAPSPPDSPA

280-350

EGRLVKAQYIPGAQAATRGLPGRAARRKPPPLTRGRSVEQSPPRERPRAAGRRGRMAEASGRRGSPRARK

350-420

ASRSQSETSLLGRASAVPSGPPKYPTAEREEPRPPRPRRGPAPTLAAQAAGSCRRWRSTAEIDAADGRRV

420-490

RPRAPAARVPGPGPSPSAPQRRLLYGCAGSDSECSAGRLGPLGRRGPAGGVGGGYGESESSASEGESPAF

490-560

SSASSDSDGSGGLVWPQQLVAATAASGGGAGAGAPAGPAKVFVKIKASHALKKKILRFRSGSLKVMTTV

560-629

MIRAFSFPVSPERGRLRGWLEGSLAGLCELHWLRERQEYRVQQALRLAQPGMGGAEAEDEEDADEDEDAAAARRAAAALEEQLEALPGLVWDLGQQLGDLSLESGGLEQESGRSSGFYEDPSSTGGPDSPPSTFCGDSGFSGSSSYGRLGPSEPRGIYASERPKSLGDASPSAPEVVGARAAVPRSFSAPYPTAGGSAGPEACSSAERRARAGPFLTPSPLHAVAMRSPRPCGRPPTDSPDAGGAGRPLDGYISALLRRRRRRGAGQPRTSPGGADGGPRRQNSVRQRPPDASPSPGSARPAREPSLERVGGHPTSPAALSRAWASSWESEAAPEPAAPPAAPSPPDSPAEGRLVKAQYIPGAQAATRGLPGRAARRKPPPLTRGRSVEQSPPRERPRAAGRRGRMAEASGRRGSPRARKASRSQSETSLLGRASAVPSGPPKYPTAEREEPRPPRPRRGPAPTLAAQAAGSCRRWRSTAEIDAADGRRVRPRAPAARVPGPGPSPSAPQRRLLYGCAGSDSECSAGRLGPLGRRGPAGGVGGGYGESESSASEGESPAFSSASSDSDGSGGLVWPQQLVAATAASGGGAGAGAPAGPAKVFVKIKASHALKKKILRFRSGSLKVMTTV

Find similar targets by:

Uniprot Keyword

Coiled coil
Complete proteome
Methylation
Phosphoprotein
Reference proteome
Wnt signaling pathway