You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
UBE2W
Ubiquitin-conjugating enzyme E2 W

Protein Summary
Description
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:20061386, PubMed:21229326). Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini (PubMed:23560854, PubMed:23696636, PubMed:25436519). Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:19111657, PubMed:21229326). In vitro catalyzes 'Lys-11'-linked polyubiquitination. UB ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000517608
  • ENSP00000428813
  • ENSG00000104343
  • ENST00000602593
  • ENSP00000473561

Symbol
  • UBC16
  • UBC16
  • UBC-16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
molecular function
0.95
histone modification site profile
0.84
microRNA
0.82
phenotype
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.53   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.53   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
43.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
43.5
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Protein-Protein Interactions (325)
1 – 10 of 325
MARCH6
Tbio
Family: Enzyme
Novelty: 0.01818691
p_int: 0.999999814
p_ni: 1.85e-7
p_wrong: 1e-9
Score: 0.239
Data Source: BioPlex,STRINGDB
NADSYN1
Tbio
Family: Enzyme
Novelty: 0.0445844
p_int: 0.999987092
p_ni: 0.000002883
p_wrong: 0.000010025
Data Source: BioPlex
CHFR
Tbio
Family: Enzyme
Novelty: 0.00904507
p_int: 0.999956578
p_ni: 2.1e-8
p_wrong: 0.000043401
Score: 0.269
Data Source: BioPlex,STRINGDB
IFT20
Tbio
Novelty: 0.03005088
p_int: 0.999856631
p_ni: 7.06e-7
p_wrong: 0.000142663
Data Source: BioPlex
RNF111
Tbio
Family: Enzyme
Novelty: 0.03059486
p_int: 0.999830467
p_ni: 1.52e-7
p_wrong: 0.000169381
Score: 0.927
Data Source: BioPlex,STRINGDB
OTUB1
Tbio
Family: Enzyme
Novelty: 0.00536726
p_int: 0.999418489
p_ni: 0.000581511
Score: 0.568
Data Source: BioPlex,STRINGDB
USP4
Tbio
Family: Enzyme
Novelty: 0.01101075
p_int: 0.999068527
p_ni: 0.000931471
p_wrong: 2e-9
Data Source: BioPlex
RNF220
Tbio
Family: Enzyme
Novelty: 0.14024436
p_int: 0.999001456
p_ni: 0.00098426
p_wrong: 0.000014284
Score: 0.902
Data Source: BioPlex,STRINGDB
USP32
Tbio
Family: Enzyme
Novelty: 0.08043957
p_int: 0.998993615
p_ni: 0.001005627
p_wrong: 7.58e-7
Score: 0.162
Data Source: BioPlex,STRINGDB
TOPORS
Tbio
Family: Enzyme
Novelty: 0.03910082
p_int: 0.998920003
p_ni: 0.001079996
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  16.53

PubMed score by year
PubTator Score  8.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: