You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
UBE2W
Ubiquitin-conjugating enzyme E2 W

Protein Summary
Description
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:20061386, PubMed:21229326). Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini (PubMed:23560854, PubMed:23696636, PubMed:25436519). Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:19111657, PubMed:21229326). In vitro catalyzes 'Lys-11'-linked polyubiquitination. UB ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000517608
  • ENSP00000428813
  • ENSG00000104343
  • ENST00000602593
  • ENSP00000473561

Symbol
  • UBC16
  • UBC16
  • UBC-16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
molecular function
0.95
histone modification site profile
0.84
microRNA
0.82
phenotype
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.07   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.07   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (325)
MARCH6
Tbio
Family:  Enzyme
Novelty:  0.01818691
p_int:  0.999999814
p_ni:  1.85e-7
p_wrong:  1e-9
Score:  0.239
Data Source:  BioPlex,STRINGDB
NADSYN1
Tbio
Family:  Enzyme
Novelty:  0.0445844
p_int:  0.999987092
p_ni:  0.000002883
p_wrong:  0.000010025
Data Source:  BioPlex
CHFR
Tbio
Family:  Enzyme
Novelty:  0.00904507
p_int:  0.999956578
p_ni:  2.1e-8
p_wrong:  0.000043401
Score:  0.269
Data Source:  BioPlex,STRINGDB
IFT20
Tbio
Novelty:  0.03005088
p_int:  0.999856631
p_ni:  7.06e-7
p_wrong:  0.000142663
Data Source:  BioPlex
RNF111
Tbio
Family:  Enzyme
Novelty:  0.03059486
p_int:  0.999830467
p_ni:  1.52e-7
p_wrong:  0.000169381
Score:  0.927
Data Source:  BioPlex,STRINGDB
OTUB1
Tbio
Family:  Enzyme
Novelty:  0.00536726
p_int:  0.999418489
p_ni:  0.000581511
Score:  0.568
Data Source:  BioPlex,STRINGDB
USP4
Tchem
Family:  Enzyme
Novelty:  0.01101075
p_int:  0.999068527
p_ni:  0.000931471
p_wrong:  2e-9
Data Source:  BioPlex
RNF220
Tbio
Family:  Enzyme
Novelty:  0.14024436
p_int:  0.999001456
p_ni:  0.00098426
p_wrong:  0.000014284
Score:  0.902
Data Source:  BioPlex,STRINGDB
USP32
Tbio
Family:  Enzyme
Novelty:  0.08043957
p_int:  0.998993615
p_ni:  0.001005627
p_wrong:  7.58e-7
Score:  0.162
Data Source:  BioPlex,STRINGDB
TOPORS
Tbio
Family:  Enzyme
Novelty:  0.03910082
p_int:  0.998920003
p_ni:  0.001079996
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
47.7
monocyte count
1
1
1
42.3
total cholesterol measurement
1
1
1
30.2
body mass index
1
1
1
11.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
47.7
monocyte count
1
42.3
total cholesterol measurement
1
30.2
body mass index
1
11.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ubiquitin conjugating enzyme E2 W
696276
Mouse
MGI:1914049
66799
Dog
ubiquitin conjugating enzyme E2 W
486999
Cow
ubiquitin conjugating enzyme E2 W
613423
Pig
ubiquitin conjugating enzyme E2 W
100152196
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ubiquitin conjugating enzyme E2 W
Mouse
Dog
ubiquitin conjugating enzyme E2 W
Cow
ubiquitin conjugating enzyme E2 W
Pig
ubiquitin conjugating enzyme E2 W
Publication Statistics
PubMed Score 18.07
PubMed score by year
PubTator Score 8.06
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title