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Tdark
TTC28
Tetratricopeptide repeat protein 28

Protein Summary
Description
During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody.
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
disease perturbation
0.87
histone modification site profile
0.84
transcription factor perturbation
0.68
cellular component
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.32   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 3   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.32   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 3   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (39)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
4
6
7
98
red blood cell distribution width
4
4
5
95.5
sex hormone-binding globulin measurement
6
2
6
92.1
optic disc size measurement
3
2
3
90.6
serum gamma-glutamyl transferase measurement
2
2
2
89.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
7
98
red blood cell distribution width
5
95.5
sex hormone-binding globulin measurement
6
92.1
optic disc size measurement
3
90.6
serum gamma-glutamyl transferase measurement
2
89.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat domain 28
VGNC:5989
458732
Macaque
tetratricopeptide repeat domain 28
717025
Mouse
MGI:2140873
209683
Rat
RGD:1594541
304558
Dog
tetratricopeptide repeat domain 28
VGNC:47948
486337
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat domain 28
Macaque
tetratricopeptide repeat domain 28
Mouse
Rat
Dog
tetratricopeptide repeat domain 28
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96AY4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (81)
1 – 10 of 81
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.999991435
p_ni:  0.000008564
Data Source:  BioPlex
HTRA4
Tbio
Family:  Enzyme
Novelty:  0.09298487
p_int:  0.99996538
p_ni:  0.000034614
p_wrong:  6e-9
Score:  0.202
Data Source:  BioPlex,STRINGDB
SNCAIP
Tbio
Novelty:  0.01355161
p_int:  0.999848461
p_ni:  0.000151524
p_wrong:  1.5e-8
Data Source:  BioPlex
ORAI1
Tchem
Family:  IC
Novelty:  0.00179685
p_int:  0.999663048
p_ni:  0.000336931
p_wrong:  2.1e-8
Data Source:  BioPlex
NCK1
Tbio
Novelty:  0.00352084
p_int:  0.999226282
p_ni:  0.000773718
Data Source:  BioPlex
GRIN2A
Tclin
Family:  IC
Novelty:  0.00060035
p_int:  0.996911335
p_ni:  0.003088635
p_wrong:  3e-8
Data Source:  BioPlex
BSG
Tbio
Novelty:  0.0010285
p_int:  0.991780334
p_ni:  0.008212602
p_wrong:  0.000007064
Data Source:  BioPlex
SDF4
Tbio
Novelty:  0.00105893
p_int:  0.991566914
p_ni:  0.008385487
p_wrong:  0.000047598
Data Source:  BioPlex
TSPYL6
Tdark
Novelty:  0.68478376
p_int:  0.989730544
p_ni:  0.010268697
p_wrong:  7.59e-7
Score:  0.151
Data Source:  BioPlex,STRINGDB
CD79A
Tbio
Novelty:  0.00118942
p_int:  0.988899414
p_ni:  0.011098958
p_wrong:  0.000001628
Data Source:  BioPlex
Publication Statistics
PubMed Score  6.32

PubMed score by year
PubTator Score  3.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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