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Tbio
FKBP10
Peptidyl-prolyl cis-trans isomerase FKBP10

Protein Summary
Description
PPIases accelerate the folding of proteins during protein synthesis. The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321562
  • ENSP00000317232
  • ENSG00000141756

Symbol
  • FKBP65
  • OI6
  • OI11
  • BRKS1
  • FKBP65
  • PPIASE
  • hFKBP65
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
protein domain
0.73
histone modification site profile
0.72
transcription factor binding site profile
0.71
tissue
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.33   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.33   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (110)
1 – 10 of 110
KISS1
Tbio
Novelty:  0.00096537
p_int:  0.942562387
p_ni:  0.057437613
Data Source:  BioPlex
TIMM10
Tbio
Family:  Enzyme
Novelty:  0.02727463
p_int:  0.908227405
p_ni:  0.091772595
Data Source:  BioPlex
CTTN
Tbio
Novelty:  0.0017962
p_int:  0.872540465
p_ni:  0.127459535
Data Source:  BioPlex
TMCC2
Tdark
Novelty:  0.21581357
p_int:  0.829016157
p_ni:  0.170983843
Score:  0.369
Data Source:  BioPlex,STRINGDB
P3H1
Tbio
Family:  Enzyme
Novelty:  0.02067711
Score:  0.853
Data Source:  STRINGDB
KDELR3
Tdark
Novelty:  0.33264767
Score:  0.85
Data Source:  STRINGDB
CRTAP
Tbio
Novelty:  0.02380647
Score:  0.836
Data Source:  STRINGDB
SERPINH1
Tbio
Novelty:  0.00106715
Score:  0.82
Data Source:  STRINGDB
PPIB
Tchem
Family:  Enzyme
Novelty:  0.00309224
Score:  0.774
Data Source:  STRINGDB
COL1A1
Tbio
Novelty:  0.00063584
Score:  0.739
Data Source:  STRINGDB
Gene Ontology Terms (4)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
4
6
95.7
reticulocyte measurement
3
3
4
94.7
heel bone mineral density
3
2
4
78.7
balding measurement
1
1
1
64.4
eosinophil count
2
1
2
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
95.7
reticulocyte measurement
4
94.7
heel bone mineral density
4
78.7
balding measurement
1
64.4
eosinophil count
2
48.5
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
FK506 binding protein 10
707881
Mouse
MGI:104769
14230
Rat
RGD:1549751
360627
Dog
FK506 binding protein 10
490975
Horse
FK506 binding protein 10
100066516
Species
Name
OMA
EggNOG
Inparanoid
Macaque
FK506 binding protein 10
Mouse
Rat
Dog
FK506 binding protein 10
Horse
FK506 binding protein 10
Publication Statistics
PubMed Score 78.33
PubMed score by year
PubTator Score 44.98
PubTator score by year