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Tbio
FKBP10
Peptidyl-prolyl cis-trans isomerase FKBP10

Protein Summary
Description
PPIases accelerate the folding of proteins during protein synthesis. The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321562
  • ENSP00000317232
  • ENSG00000141756

Symbol
  • FKBP65
  • OI6
  • OI11
  • BRKS1
  • FKBP65
  • PPIASE
  • hFKBP65
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
protein domain
0.73
histone modification site profile
0.72
transcription factor binding site profile
0.71
tissue
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.31   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.31   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (110)
1 – 10 of 110
KISS1
Tbio
Novelty: 0.00111063
p_int: 0.942562387
p_ni: 0.057437613
Data Source: BioPlex
TIMM10
Tbio
Family: Enzyme
Novelty: 0.03711012
p_int: 0.908227405
p_ni: 0.091772595
Data Source: BioPlex
CTTN
Tbio
Novelty: 0.00214976
p_int: 0.872540465
p_ni: 0.127459535
Data Source: BioPlex
TMCC2
Tdark
Novelty: 0.26054591
p_int: 0.829016157
p_ni: 0.170983843
Score: 0.369
Data Source: BioPlex,STRINGDB
P3H1
Tbio
Family: Enzyme
Novelty: 0.02610289
Score: 0.853
Data Source: STRINGDB
KDELR3
Tdark
Novelty: 0.88948787
Score: 0.85
Data Source: STRINGDB
CRTAP
Tbio
Novelty: 0.03231673
Score: 0.836
Data Source: STRINGDB
SERPINH1
Tbio
Novelty: 0.00133506
Score: 0.82
Data Source: STRINGDB
PPIB
Tchem
Family: Enzyme
Novelty: 0.00490532
Score: 0.774
Data Source: STRINGDB
COL1A1
Tbio
Novelty: 0.00095231
Score: 0.739
Data Source: STRINGDB
Publication Statistics
PubMed Score  57.31

PubMed score by year
PubTator Score  44.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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