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Tbio
MIB2
E3 ubiquitin-protein ligase MIB2

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion. [provided by RefSeq, Mar 2017]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
protein domain
0.85
transcription factor binding site profile
0.79
transcription factor perturbation
0.74
transcription factor
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.67   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.67   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (22)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

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Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Constitutive Signaling by NOTCH1 HD Domain Mutants
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Constitutive Signaling by NOTCH1 HD Domain Mutants
Protein-Protein Interactions (379)
1 – 10 of 379
PMCH
Tbio
Novelty: 0.005002
p_int: 0.999999989
p_ni: 1.1e-8
Data Source: BioPlex
IKZF5
Tbio
Family: TF
Novelty: 1
p_int: 0.99999983
p_ni: 1.7e-7
Score: 0.388
Data Source: BioPlex,STRINGDB
IKZF1
Tbio
Family: TF
Novelty: 0.00201134
p_int: 0.999999601
p_ni: 3.95e-7
p_wrong: 5e-9
Score: 0.449
Data Source: BioPlex,STRINGDB
P2RY1
Tchem
Family: GPCR
Novelty: 0.00263409
p_int: 0.999999426
p_ni: 5.72e-7
p_wrong: 1e-9
Score: 0.197
Data Source: BioPlex,STRINGDB
NUP58
Tbio
Novelty: 0.15956345
p_int: 0.999997635
p_ni: 0.000002365
p_wrong: 1e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
F9
Tchem
Family: Enzyme
Novelty: 0.00032545
p_int: 0.99996177
p_ni: 0.000038228
p_wrong: 1e-9
Score: 0.184
Data Source: BioPlex,STRINGDB
PI15
Tbio
Family: Enzyme
Novelty: 0.04540369
p_int: 0.999931305
p_ni: 0.000068666
p_wrong: 2.9e-8
Data Source: BioPlex
CHRNB4
Tclin
Family: IC
Novelty: 0.02388015
p_int: 0.998788785
p_ni: 0.001205532
p_wrong: 0.000005683
Data Source: BioPlex
PLA2G16
Tbio
Novelty: 0.00826239
p_int: 0.997683964
p_ni: 0.002316031
p_wrong: 6e-9
Data Source: BioPlex
MACC1
Tbio
Novelty: 0.00874951
p_int: 0.997375824
p_ni: 0.001347714
p_wrong: 0.001276462
Data Source: BioPlex
Publication Statistics
PubMed Score  53.67

PubMed score by year
PubTator Score  8.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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