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Tbio
MIB2
E3 ubiquitin-protein ligase MIB2

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion. [provided by RefSeq, Mar 2017]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
protein domain
0.85
transcription factor binding site profile
0.79
transcription factor perturbation
0.74
transcription factor
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.17   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.17   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (379)
PMCH
Tbio
Novelty:  0.00600873
p_int:  0.999999989
p_ni:  1.1e-8
Data Source:  BioPlex
IKZF5
Tbio
Family:  TF
Novelty:  0.36596327
p_int:  0.99999983
p_ni:  1.7e-7
Score:  0.388
Data Source:  BioPlex,STRINGDB
IKZF1
Tbio
Family:  TF
Novelty:  0.0016117
p_int:  0.999999601
p_ni:  3.95e-7
p_wrong:  5e-9
Score:  0.449
Data Source:  BioPlex,STRINGDB
P2RY1
Tchem
Family:  GPCR
Novelty:  0.00203299
p_int:  0.999999426
p_ni:  5.72e-7
p_wrong:  1e-9
Score:  0.197
Data Source:  BioPlex,STRINGDB
NUP58
Tbio
Novelty:  0.08797454
p_int:  0.999997635
p_ni:  0.000002365
p_wrong:  1e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
F9
Tchem
Family:  Enzyme
Novelty:  0.00032127
p_int:  0.99996177
p_ni:  0.000038228
p_wrong:  1e-9
Score:  0.184
Data Source:  BioPlex,STRINGDB
PI15
Tbio
Family:  Enzyme
Novelty:  0.02244161
p_int:  0.999931305
p_ni:  0.000068666
p_wrong:  2.9e-8
Data Source:  BioPlex
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
p_int:  0.998788785
p_ni:  0.001205532
p_wrong:  0.000005683
Data Source:  BioPlex
PLA2G16
Tchem
Novelty:  0.02310886
p_int:  0.997683964
p_ni:  0.002316031
p_wrong:  6e-9
Data Source:  BioPlex
MACC1
Tbio
Novelty:  0.00737376
p_int:  0.997375824
p_ni:  0.001347714
p_wrong:  0.001276462
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Constitutive Signaling by NOTCH1 HD Domain Mutants
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Constitutive Signaling by NOTCH1 HD Domain Mutants
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
2
3
78.1
body height
2
2
2
73.4
serum albumin measurement
1
1
1
33.1
visceral adipose tissue measurement
1
1
1
11.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
78.1
body height
2
73.4
serum albumin measurement
1
33.1
visceral adipose tissue measurement
1
11.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
mindbomb E3 ubiquitin protein ligase 2
708438
Mouse
MGI:2679684
76580
Rat
RGD:1359469
474147
Dog
mindbomb E3 ubiquitin protein ligase 2
VGNC:43218
479566
Horse
mindbomb E3 ubiquitin protein ligase 2
VGNC:20170
100065291
Species
Name
OMA
EggNOG
Inparanoid
Macaque
mindbomb E3 ubiquitin protein ligase 2
Mouse
Rat
Dog
mindbomb E3 ubiquitin protein ligase 2
Horse
mindbomb E3 ubiquitin protein ligase 2
Publication Statistics
PubMed Score 22.17
PubMed score by year
PubTator Score 8.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title