You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RAB37
Ras-related protein Rab-37

Protein Summary
Description
Rab proteins are low molecular mass GTPases that are critical regulators of vesicle trafficking. For additional background information on Rab proteins, see MIM 179508.[supplied by OMIM, Apr 2006]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392612
  • ENSP00000376388
  • ENSG00000172794
  • ENST00000392613
  • ENSP00000376389
  • ENST00000392614
  • ENSP00000376390
  • ENST00000402449
  • ENSP00000383934
  • ENST00000481224
  • ENSP00000436563
  • ENST00000613645
  • ENSP00000483155
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
kinase perturbation
0.76
gene perturbation
0.74
transcription factor
0.71
interacting protein
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.61   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.61   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
3
3
96.4
C-reactive protein measurement
4
4
5
95.2
lymphocyte count
3
4
4
92.8
myeloid white cell count
2
2
2
91.2
leukocyte count
2
5
5
89.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
96.4
C-reactive protein measurement
5
95.2
lymphocyte count
4
92.8
myeloid white cell count
2
91.2
leukocyte count
5
89.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB37, member RAS oncogene family
VGNC:14187
735694
Macaque
RAB37, member RAS oncogene family
698842
Mouse
MGI:1929945
58222
Dog
RAB37, member RAS oncogene family
VGNC:45279
483298
Horse
RAB37, member RAS oncogene family
VGNC:22113
100052585
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB37, member RAS oncogene family
Macaque
RAB37, member RAS oncogene family
Mouse
Dog
RAB37, member RAS oncogene family
Horse
RAB37, member RAS oncogene family
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96AX2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Reactome
Neutrophil degranulation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism of proteins
Neutrophil degranulation
Post-translational protein modification
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (207)
1 – 10 of 207
RAB5A
Tbio
Family:  Enzyme
Novelty:  0.00111347
Score:  0.943
Data Source:  STRINGDB
RAB23
Tbio
Family:  Enzyme
Novelty:  0.01686155
Score:  0.923
Data Source:  STRINGDB
RAB34
Tbio
Family:  Enzyme
Novelty:  0.03645677
Score:  0.922
Data Source:  STRINGDB
RAB34
Tbio
Novelty:  0.03645677
Score:  0.922
Data Source:  STRINGDB
RAB32
Tbio
Family:  Enzyme
Novelty:  0.02514559
Score:  0.922
Data Source:  STRINGDB
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
Score:  0.922
Data Source:  STRINGDB
RAB20
Tbio
Family:  Enzyme
Novelty:  0.06768944
Score:  0.922
Data Source:  STRINGDB
RAB3C
Tbio
Family:  Enzyme
Novelty:  0.06291754
Score:  0.921
Data Source:  STRINGDB
RAB38
Tbio
Family:  Enzyme
Novelty:  0.02651645
Score:  0.92
Data Source:  STRINGDB
RAB39B
Tbio
Family:  Enzyme
Novelty:  0.02362498
Score:  0.919
Data Source:  STRINGDB
Publication Statistics
PubMed Score  17.61

PubMed score by year
PubTator Score  9.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: