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Tbio
CIDEC
Cell death activator CIDE-3

Protein Summary
Description
Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336832
  • ENSP00000338642
  • ENSG00000187288
  • ENST00000423850
  • ENSP00000400649
  • ENST00000430427
  • ENSP00000408631
  • ENST00000455015
  • ENSP00000392975
  • ENST00000618572
  • ENSP00000483641

Symbol
  • FSP27
  • CIDE3
  • FPLD5
  • FSP27
  • CIDE-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.66
small molecule perturbation
0.61
cell line
0.58
cell type or tissue
0.51
biological process
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.99   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.99   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
PRSS2
Tchem
Family:  Enzyme
Novelty:  0.00959404
p_int:  0.971629401
p_ni:  0.006706257
p_wrong:  0.021664342
Score:  0.269
Data Source:  BioPlex,STRINGDB
TOP1
Tclin
Family:  Enzyme
Novelty:  0.00019573
p_int:  0.910968099
p_ni:  0.089031901
Score:  0.252
Data Source:  BioPlex,STRINGDB
CIDEA
Tbio
Novelty:  0.00901749
Score:  0.952
Data Source:  Reactome,STRINGDB
PLIN1
Tbio
Novelty:  0.00200378
Score:  0.933
Data Source:  STRINGDB
DFFB
Tbio
Novelty:  0.00475349
Score:  0.821
Data Source:  STRINGDB
DFFA
Tbio
Novelty:  0.00253065
Score:  0.723
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.72
Data Source:  STRINGDB
PLIN4
Tbio
Novelty:  0.02456188
Score:  0.716
Data Source:  STRINGDB
PLIN2
Tbio
Novelty:  0.0020792
Score:  0.696
Data Source:  STRINGDB
PLIN3
Tbio
Novelty:  0.00975965
Score:  0.69
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Assembly of active LPL and LIPC lipase complexes (R-HSA-8963889)

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Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of active LPL and LIPC lipase complexes
Reactome
Lipid particle organization
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Name
Explore in Pharos
Explore in Source
Assembly of active LPL and LIPC lipase complexes
Lipid particle organization
Metabolism
Metabolism of lipids
Plasma lipoprotein assembly, remodeling, and clearance
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
40.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
40.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell death inducing DFFA like effector c
VGNC:7035
460156
Macaque
cell death inducing DFFA like effector c
703021
Mouse
MGI:95585
14311
Rat
RGD:1562113
500292
Dog
cell death inducing DFFA like effector c
VGNC:39272
484662
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell death inducing DFFA like effector c
Macaque
cell death inducing DFFA like effector c
Mouse
Rat
Dog
cell death inducing DFFA like effector c
Publication Statistics
PubMed Score 117.99
PubMed score by year
PubTator Score 46.31
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title