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Tbio
ZUP1
Zinc finger-containing ubiquitin peptidase 1

Protein Summary
Description
Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains (PubMed:29576528, PubMed:29563501, PubMed:29476094). Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage (PubMed:29576528, PubMed:29576527). Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress (PubMed:29563501). This gene encodes a protein containing zinc finger motifs and a cysteine peptidase domain. The encoded protein functions as a K63-specific de-ubiquitinating enzyme that specifically cleaves long K63-linked polyubiquitin chains in the middle of a chain (i.e. "endo cleavage) rather than by removing the terminal ubiquitin from a chain. This enzyme is thought to be involved in the regulation of DNA ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368576
  • ENSP00000357565
  • ENSG00000153975

Symbol
  • C6orf113
  • ZUFSP
  • DUB
  • ZUFSP
  • C6orf113
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.69
virus perturbation
0.64
tissue sample
0.62
histone modification site profile
0.53
transcription factor
0.53


Related Tools
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.25   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.25   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger containing ubiquitin peptidase 1
VGNC:8574
462962
Macaque
zinc finger with UFM1 specific peptidase domain
718059
Mouse
MGI:1919830
72580
Rat
RGD:1307672
294390
Dog
zinc finger containing ubiquitin peptidase 1
VGNC:48863
476272
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger containing ubiquitin peptidase 1
Macaque
zinc finger with UFM1 specific peptidase domain
Mouse
Rat
Dog
zinc finger containing ubiquitin peptidase 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96AP4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (33)
1 – 10 of 33
TCEAL1
Tbio
Novelty:  0.02210924
p_int:  0.998224019
p_ni:  9.4e-8
p_wrong:  0.001775888
Score:  0.617
Data Source:  BioPlex,STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.863
Data Source:  STRINGDB
RPA3
Tbio
Novelty:  0.00887858
Score:  0.853
Data Source:  STRINGDB
UFM1
Tbio
Novelty:  0.0215914
Score:  0.817
Data Source:  STRINGDB
MINDY1
Tbio
Novelty:  0.31540765
Score:  0.793
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.781
Data Source:  STRINGDB
ZNF76
Tbio
Family:  TF
Novelty:  0.22129218
Score:  0.747
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.742
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.737
Data Source:  STRINGDB
UBD
Tbio
Novelty:  0.00657227
Score:  0.704
Data Source:  STRINGDB
Publication Statistics
PubMed Score  7.25

PubMed score by year
PubTator Score  3.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer