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Tbio
ACD
Adrenocortical dysplasia protein homolog

Protein Summary
Description
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis. This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000620338
  • ENSP00000483117
  • ENSG00000102977
  • ENST00000647559
  • ENSP00000497937

Symbol
  • PIP1
  • PTOP
  • TINT1
  • TPP1
  • PIP1
  • PTOP
  • TPP1
  • TINT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.89
transcription factor perturbation
0.68
cellular component
0.65
tissue
0.57
tissue sample
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.52   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 317   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.52   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 317   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (91)
TINF2
Tbio
Novelty:  0.0064505
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
POT1
Tbio
Novelty:  0.01042607
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
TERF1
Tbio
Family:  TF
Novelty:  0.00174529
p_int:  0.999998242
p_ni:  0.000001758
Score:  0.997
Data Source:  BioPlex,STRINGDB
TERF2IP
Tchem
Novelty:  0.06285957
p_int:  0.993204989
p_ni:  0.006795011
Score:  0.992
Data Source:  BioPlex,STRINGDB
POF1B
Tbio
Novelty:  0.1232792
p_int:  0.841322725
p_ni:  0.158677275
Score:  0.181
Data Source:  BioPlex,STRINGDB
IGHG2
Tclin
p_int:  0.831246912
p_ni:  0.107266778
p_wrong:  0.061486311
Data Source:  BioPlex
USP7
Tchem
Family:  Enzyme
Novelty:  0.00412878
p_int:  0.756153613
p_ni:  0.243846387
Score:  0.515
Data Source:  BioPlex,STRINGDB
TERF2
Tchem
Family:  TF
Novelty:  0.01003649
Score:  0.994
Data Source:  STRINGDB
BRCA1
Tchem
Novelty:  0.00011146
Score:  0.954
Data Source:  STRINGDB
DCLRE1B
Tbio
Family:  Enzyme
Novelty:  0.0598925
Score:  0.927
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Base-Excision Repair, AP Site Formation
Reactome
Cell Cycle
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Base-Excision Repair, AP Site Formation
Cell Cycle
Cellular Senescence
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
2
2
90.2
sleep duration
1
1
1
79.9
lymphocyte count
2
1
2
78.1
serum non-albumin protein measurement
1
1
1
71.9
red blood cell distribution width
1
1
1
59.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
90.2
sleep duration
1
79.9
lymphocyte count
2
78.1
serum non-albumin protein measurement
1
71.9
red blood cell distribution width
1
59.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ACD, shelterin complex subunit and telomerase recruitment factor
VGNC:9384
454170
Macaque
ACD, shelterin complex subunit and telomerase recruitment factor
699230
Mouse
MGI:87873
497652
Rat
RGD:1565053
307798
Dog
ACD, shelterin complex subunit and telomerase recruitment factor
VGNC:37502
487931
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ACD, shelterin complex subunit and telomerase recruitment factor
Macaque
ACD, shelterin complex subunit and telomerase recruitment factor
Mouse
Rat
Dog
ACD, shelterin complex subunit and telomerase recruitment factor
Publication Statistics
PubMed Score 194.52
PubMed score by year
PubTator Score 89.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title