You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MRGPRF
Mas-related G-protein coupled receptor member F

Protein Summary
Description
Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309099
  • ENSP00000309782
  • ENSG00000172935
  • ENST00000441623
  • ENSP00000403660

Symbol
  • GPR140
  • GPR168
  • MRGF
  • RTA
  • MRGF
  • GPR140
  • GPR168
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.67
protein domain
0.58
transcription factor
0.58
cell type or tissue
0.57
cell line
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.45   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.45   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (21)
NPFF
Tbio
Novelty:  0.00489546
Score:  0.754
Data Source:  STRINGDB
OR7C2
Tdark
Family:  oGPCR
Novelty:  2.64
Score:  0.617
Data Source:  STRINGDB
OR5C1
Tdark
Family:  oGPCR
Novelty:  1.6529517
Score:  0.571
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.54
Data Source:  STRINGDB
MENT
Tbio
Novelty:  0.06352513
Score:  0.534
Data Source:  STRINGDB
MYEOV
Tbio
Novelty:  0.04142875
Score:  0.518
Data Source:  STRINGDB
LIX1L
Tdark
Novelty:  0.5277858
Score:  0.498
Data Source:  STRINGDB
OR4X1
Tdark
Family:  oGPCR
Novelty:  1.05588852
Score:  0.479
Data Source:  STRINGDB
COL16A1
Tbio
Novelty:  0.11147945
Score:  0.47
Data Source:  STRINGDB
COPZ2
Tdark
Novelty:  0.21561497
Score:  0.469
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
6
7
0
1.6
99.6
heel bone mineral density
3
3
9
96.6
hair colour measurement
1
1
1
87.2
BMI-adjusted hip circumference
2
4
4
81.6
suntan
1
1
1
79.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.6
99.6
heel bone mineral density
9
96.6
hair colour measurement
1
87.2
BMI-adjusted hip circumference
4
81.6
suntan
1
79.5
Find similar targets by:
IDG Resources
Genetic Construct
MRGPRF-Tango
image for MRGPRF-Tango
Details:
  • Vector:  addgene66437
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • MRGPRF-Tango
Order Genetic Construct from:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MAS related GPR family member F
VGNC:3243
466687
Mouse
MGI:2384823
211577
Rat
RGD:708478
266762
Dog
MAS related GPR family member F
VGNC:43363
483684
Horse
MAS related GPR family member F
VGNC:20312
100049010
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MAS related GPR family member F
Mouse
Rat
Dog
MAS related GPR family member F
Horse
MAS related GPR family member F
Publication Statistics
PubMed Score 13.45
PubMed score by year
PubTator Score 342.13
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title