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Tbio
SLC25A46
Solute carrier family 25 member 46

Protein Summary
Description
May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission. This gene encodes a mitochondrial solute carrier protein family member. It functions in promoting mitochondrial fission, and prevents the formation of hyperfilamentous mitochondria. Mutation of this gene results in neuropathy and optic atrophy. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355943
  • ENSP00000348211
  • ENSG00000164209
  • ENST00000447245
  • ENSP00000399717
  • ENST00000504098
  • ENSP00000425708

Symbol
  • TB1
  • HMSN6B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
histone modification site profile
0.9
disease perturbation
0.83
transcription factor perturbation
0.74
tissue sample
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.69   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.69   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
4
2
1.1
83.6
5
5
0
1.1
83
2
1
0
1.2
46.6
Eczema
1
1
0
1.1
46.4
allergic sensitization measurement
2
2
0
1.2
21.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
83.6
0
1.1
83
0
1.2
46.6
Eczema
0
1.1
46.4
allergic sensitization measurement
0
1.2
21.4
Protein-Protein Interactions (69)
1 – 10 of 69
SLC22A6
Tclin
Family: Transporter
Novelty: 0.00389149
p_int: 0.995095442
p_ni: 0.004904558
Score: 0.296
Data Source: BioPlex,STRINGDB
SLC22A16
Tbio
Family: Transporter
Novelty: 0.03379851
p_int: 0.989204341
p_ni: 0.01079565
p_wrong: 9e-9
Data Source: BioPlex
CMKLR1
Tchem
Family: GPCR
Novelty: 0.00893083
p_int: 0.989098573
p_ni: 0.010900299
p_wrong: 0.000001129
Data Source: BioPlex
SLC2A9
Tbio
Family: Transporter
Novelty: 0.00683926
p_int: 0.987983251
p_ni: 0.012016736
p_wrong: 1.3e-8
Data Source: BioPlex
MFAP4
Tbio
Novelty: 0.02023782
p_int: 0.98016859
p_ni: 0.019829067
p_wrong: 0.000002343
Data Source: BioPlex
SLC15A1
Tchem
Family: Transporter
Novelty: 0.00149723
p_int: 0.966079613
p_ni: 0.0234385
p_wrong: 0.010481887
Data Source: BioPlex
SLC22A15
Tdark
Family: Transporter
Novelty: 0.22792289
p_int: 0.952216125
p_ni: 0.04647166
p_wrong: 0.001312215
Data Source: BioPlex
SLC22A2
Tchem
Family: Transporter
Novelty: 0.00439263
p_int: 0.949306297
p_ni: 0.0442942
p_wrong: 0.006399503
Data Source: BioPlex
PDCD1
Tclin
Novelty: 0.000448
p_int: 0.938919241
p_ni: 0.061029362
p_wrong: 0.000051397
Data Source: BioPlex
APLNR
Tchem
Family: GPCR
Novelty: 0.00224203
p_int: 0.934939742
p_ni: 0.065045341
p_wrong: 0.000014917
Data Source: BioPlex
Publication Statistics
PubMed Score  36.69

PubMed score by year
PubTator Score  10.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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