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Tbio
FUBP1
Far upstream element-binding protein 1

Protein Summary
Description
Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294623
  • ENSP00000294623
  • ENSG00000162613
  • ENST00000370768
  • ENSP00000359804

Symbol
  • FBP
  • FUBP
  • hDH V
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.99
protein complex
0.96
transcription factor perturbation
0.96
transcription factor binding site profile
0.91


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.97   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.97   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (161)
PUF60
Tbio
Novelty:  0.02667356
Score:  0.99
Data Source:  STRINGDB
FUBP3
Tbio
Novelty:  0.0393152
Score:  0.896
Data Source:  STRINGDB
HNRNPF
Tbio
Novelty:  0.01833966
Score:  0.872
Data Source:  STRINGDB
KHSRP
Tbio
Novelty:  0.01131549
Score:  0.867
Data Source:  STRINGDB
TIAL1
Tbio
Novelty:  0.01126806
Score:  0.866
Data Source:  STRINGDB
PCBP1
Tbio
Novelty:  0.00906713
Score:  0.856
Data Source:  STRINGDB
KHDRBS1
Tbio
Novelty:  0.00647929
Score:  0.848
Data Source:  STRINGDB
PKM
Tchem
Family:  Kinase
Novelty:  0.00076567
Score:  0.806
Data Source:  STRINGDB
U2AF2
Tbio
Novelty:  0.00590935
Score:  0.787
Data Source:  STRINGDB
AIMP2
Tchem
Family:  Enzyme
Novelty:  0.03283387
Score:  0.782
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
80.3
body mass index
4
2
9
78.7
diastolic blood pressure
1
1
1
73.5
self reported educational attainment
3
3
3
68.3
waist circumference
2
2
2
68.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
80.3
body mass index
9
78.7
diastolic blood pressure
1
73.5
self reported educational attainment
3
68.3
waist circumference
2
68.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
far upstream element binding protein 1
VGNC:7407
456968
Macaque
far upstream element binding protein 1
707102
Mouse
MGI:1196294
51886
Rat
RGD:1591892
654496
Dog
far upstream element binding protein 1
100855608
Species
Name
OMA
EggNOG
Inparanoid
Chimp
far upstream element binding protein 1
Macaque
far upstream element binding protein 1
Mouse
Rat
Dog
far upstream element binding protein 1
Publication Statistics
PubMed Score 65.97
PubMed score by year
PubTator Score 60.02
PubTator score by year
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Related Publications
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PMID
Year
Title